CAJ | 학술논문

目的评价聚乙二醇干扰素α-2a对慢性丙型肝炎患者生活质量(QOL)的影响.方法对干扰素治疗前的慢性丙型肝炎患者(A组102例)和健康对照人员(B组44例)进行生活质量综合评定问卷-74 (GQOLI-74)测定,比较两组QOL状况.A组患者中,分别给予聚乙二醇干扰素α-2a及利巴韦林治疗1年(A1组72例)或不进行任何抗病毒治疗(A2组30例).分别在治疗结束时及治疗结束半年后对各组患者进行GQOLI-74量表测定,比较A1和A2组患者各时段QOL差异.结果 A组患者QOL状况除心理功能(P＞0.05)外,GQOI-74量表中其他维度及总分均较B组下降(P值均＜0,05).无论干扰素治疗结束时还是治疗结束后半年时,A1组患者躯体功能、心理功能、社会功能维度及总分值均高于同期的A2组患者(P值均＜0.05).治疗结束时,A1组患者躯体功能、心理功能、社会功能维度及总分值均较治疗前高(P值均＜ 0.05)；治疗结束半年后,A1组患者社会功能维度较治疗结束时高(P＜0.05).结论慢性丙型肝炎患者的QOL低于健康对照人员,聚乙二醇干扰素α-2a可以改善慢性丙型肝炎患者QOL.
목적 평개취을이순간우소α-2a대만성병형간염환자생활질량(QOL)적영향.방법 대간우소치료전적만성병형간염환자(A조102례)화건강대조인원(B조44례)진행생활질량종합평정문권-74 (GQOLI-74)측정,비교량조QOL상황.A조환자중,분별급여취을이순간우소α-2a급리파위림치료1년(A1조72례)혹불진행임하항병독치료(A2조30례).분별재치료결속시급치료결속반년후대각조환자진행GQOLI-74량표측정,비교A1화A2조환자각시단QOL차이.결과 A조환자QOL상황제심리공능(P＞0.05)외,GQOI-74량표중기타유도급총분균교B조하강(P치균＜0,05).무론간우소치료결속시환시치료결속후반년시,A1조환자구체공능、심리공능、사회공능유도급총분치균고우동기적A2조환자(P치균＜0.05).치료결속시,A1조환자구체공능、심리공능、사회공능유도급총분치균교치료전고(P치균＜ 0.05)；치료결속반년후,A1조환자사회공능유도교치료결속시고(P＜0.05).결론 만성병형간염환자적QOL저우건강대조인원,취을이순간우소α-2a가이개선만성병형간염환자QOL.
Objective To evaluate the quality of life (QOL) in the patients with chronic hepatitis C (CHC)after PEG-Interferon α-2a therapy.Methods A study based on 102 CHC patients (group A,before PEG-Interferon α-2a therapy,T0) and 44 healthy persons (group B) was carried out using the general quality of life inventory (GQOLI-74) questionaire,and QOL were compared between the two groups.Patients in group A were divided into subgroup A1 (72 patients ) which was given PEG-Interferon α-2a plus Ribavirin for one year and subgroup A2 (30 patients ) without any antivirus therapy.QOL of patients in these two subgroups was investigated using GQOLI-74 questionaire on the end of PEG-Interferon α-2a plus Ribavirin therapy (T1) and half one year after the end of PEG-Interferon α-2a plus Ribavirin therapy (T2).QOL of CHC patients (group A1 and A2) were compared at T0,T1 and T2,respectively.Results Compared with group B,patients in group A had lower QOL (P ＜ 0.05) on other scales and total scores of the GQOLI-74 questionaire except psychological function( P ＞ 0.05).Both on T1 and T2,patients in subgroup A1 had higher QOL on physical function,psychological function,social function and total scores than patients in subgroup A2 at the same time (P ＜ 0.05).Patients in subgroup A1 at T1 had higher QOL on physical function,psychological function,social function and total scores than at T0 ( P ＜ 0.05).Patients in subgroup A1 at T2 had higher QOL on social function than that at T1 (P ＜ 0.05).Conchusions QOL of CHC patients is more impaired than healthy persons.PEG-Interferon α-2a therapy will improve the QOL.