CAJ | 학술논문

4E-BP1是真核细胞翻译起始因子4E(eIF4E)的特异性抑制物，近年研究显示，磷酸化形式的4E-BP1(P-4E-BP1)在多种恶性肿瘤如乳腺癌、宫颈癌、甲状腺、前列腺癌、大肠癌等中存在过表达，并且其表达与肿瘤的大小、侵袭、转移能力、预后等临床病理特征密切相关。因此，阐明P-4E-BP1的表达与肿瘤的生物学行为将有助于全面了解恶性肿瘤的发生、发展、侵袭及转移机制，同时对指导临床诊断和治疗，判断预后有重大意义。更重要的是，P-4E-BP1有可能成为治疗肿瘤的新靶点，为临床治疗肿瘤提供新思路。
4E-BP1시진핵세포번역기시인자4E(eIF4E)적특이성억제물，근년연구현시，린산화형식적4E-BP1(P-4E-BP1)재다충악성종류여유선암、궁경암、갑상선、전렬선암、대장암등중존재과표체，병차기표체여종류적대소、침습、전이능력、예후등림상병리특정밀절상관。인차，천명P-4E-BP1적표체여종류적생물학행위장유조우전면료해악성종류적발생、발전、침습급전이궤제，동시대지도림상진단화치료，판단예후유중대의의。경중요적시，P-4E-BP1유가능성위치료종류적신파점，위림상치료종류제공신사로。
4E-BP1 is the specific inhibitor of eukaryotic initiation factor 4E, recent studies have shown, phosphorylated 4E-binding protein 1(P-4E-BP1)overexpression has been observed in a variety of human cancers, including breast cancer, cervical cancer, thyroid cancer, prostate cancer, colorectal cancer, et al. Its expression level is associated with tumor size, invasion, metastasis, prognosis and other clinical and pathological features. Thus evaluate P-4E-BP1 expression level which is associated with tumor biological behavior will help us better understand the etiology, development, invasion and metastasis mechanisms of cancer.Moreover, P-4E-BP1 may become a new target for cancer treatment and provide new ideas for the clinical cancer treatment.