CAJ | 학술논문

目的探讨2型糖尿病(T2DM)酮症患者血清脂联索(APN)水平的变化,以及其与血脂等因素的相关性.方法选择T2DM酮症患者(酮症组)52例,无酮症患者(非酮症组)58例;另选健康个体54例为正常对照(NC)组.分别测身高、体重、空腹血清APN、血糖、HbA<,1>c、血脂.结果两组患者血清APN水平明显低于NC组(P<0.01).酮症组APN水平明显低于非酮症组(P<0.01).血清APN水平与HbA<,1>c、TC、TG呈负相关,与HDL-C呈正相关,酮症组患者酮症纠正后APN水平与非酮症患者相比,差异无统计学意义.结论糖尿病酮症期间APN水平明显降低,酮症纠正后恢复.
목적 탐토2형당뇨병(T2DM)동증환자혈청지련색(APN)수평적변화,이급기여혈지등인소적상관성.방법 선택T2DM동증환자(동증조)52례,무동증환자(비동증조)58례;령선건강개체54례위정상대조(NC)조.분별측신고、체중、공복혈청APN、혈당、HbA<,1>c、혈지.결과 량조환자혈청APN수평명현저우NC조(P<0.01).동증조APN수평명현저우비동증조(P<0.01).혈청APN수평여HbA<,1>c、TC、TG정부상관,여HDL-C정정상관,동증조환자동증규정후APN수평여비동증환자상비,차이무통계학의의.결론 당뇨병동증기간APN수평명현강저,동증규정후회복.
Objective To investigate the change of serum adiponectin level and the correlation of serum adiponectin with serum lipids.Methods 110 T2DM patients were devided into diabetic ketosis group,and non-diabetic ketosis group.54 healthy persons were chosen as normal control group.Patients’ height,weight,BMI were measured respectively and fasting blood samples were taken for detecting adiponectin,glucose,HbA1c and lipids.Results Serum adiponectin was significantly lower in T2DM patients than in normal control group(P<0.01).Serum adiponectin level was lower in diabetic ketosis patients than in non-diabetic ketosis patients(P<0.01) and negatively correlated with HbA1c,TC,TG and positively correlated with HDL-C during ketosis period.Conclusion Adiponectin level becomes lower after diabetic ketosis and returns to the pre-ketosis level after ketosis disappars