CAJ | 학술논문

目的:研究多囊卵巢综合征(PCOS)患者的血清抗苗勒氏管激素(AMH)水平,并初步探讨其在PCOS中的诊断价值.方法:收集2006年6月至12月在我院妇产科就诊的47例PCOS患者(研究组)和年龄匹配的40例健康女性(对照组),应用酶联免疫吸附(ELISA)法检测血清AMH水平.结果:研究组的血清AMH水平明显高于对照组(9.85±4.93 ng/ml vs 7.13±3.02 ng/ml,P=0.002).血清AMH的曲线下面积在总体人群为0.664(P=0.008),以血清AMH 8 ng/ml为相对最佳的诊断界值,敏感度为61.7%,特异度为70.0%.结论:PCOS患者的血清AMH水平明显增高,血清AMH测定对于PCOS的诊断效能较低.
목적:연구다낭란소종합정(PCOS)환자적혈청항묘륵씨관격소(AMH)수평,병초보탐토기재PCOS중적진단개치.방법:수집2006년6월지12월재아원부산과취진적47례PCOS환자(연구조)화년령필배적40례건강녀성(대조조),응용매련면역흡부(ELISA)법검측혈청AMH수평.결과:연구조적혈청AMH수평명현고우대조조(9.85±4.93 ng/ml vs 7.13±3.02 ng/ml,P=0.002).혈청AMH적곡선하면적재총체인군위0.664(P=0.008),이혈청AMH 8 ng/ml위상대최가적진단계치,민감도위61.7%,특이도위70.0%.결론:PCOS환자적혈청AMH수평명현증고,혈청AMH측정대우PCOS적진단효능교저.
Objective:To detect the serum anti-Müllerian hormone (AMH) level of patients with polycystic ovary syndrome (PCOS), and to explore the diagnostic value of serum AMH measurement in PCOS.Methods:47 patients with PCOS and 40 healthy females were enrolled from June 2006 to December 2006 in the Second Affiliated Hospital of Sun Yat-sen University. Serum AMH levels were measured by enzyme linked immunosorbent assay (ELISA). Results: The mean serum AMH level in PCOS group was significantly higher than control group (9.85±4.93 ng/ml vs 7.13±3.02ng/ml, P=0.002), which is similar in adult PCOS patients and controls (10.64±5.47 ng/ml vs 7.01 ± 2.43 ng/ml, P=0.005). No difference was found in serum AMH of adolescent PCOS patients and controls (8.95± 4.18 ng/ml vs 7.26± 3.58 ng/ml, P = 0.168). The areas under the ROC curve for AMH in all PCOS population, adults and adolescents were 0.664 (P=0.008), 0.714 (P = 0.015), and 0.614 (P = 0.208), respectively. The best compromise between specificity (70.0%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/ml. Conclusions: Serum AMH level was elevated in patients with PCOS. Serum AMH measurement offers a relatively poor sensitivity of 61.7% and a specificity of 70% with a cut off value at 8 ng/ml, suggesting the diagnostic value of AMH was limited.