中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
2期
112-115
,共4页
黄东辉%郭征东%唐先格%孙田歌
黃東輝%郭徵東%唐先格%孫田歌
황동휘%곽정동%당선격%손전가
糖尿病,2型%下肢血管病变%内脏脂肪素%内膜中层厚度,下肢动脉
糖尿病,2型%下肢血管病變%內髒脂肪素%內膜中層厚度,下肢動脈
당뇨병,2형%하지혈관병변%내장지방소%내막중층후도,하지동맥
Diabetes mellitus, type 2%Lower limb vascular disease% Visfatin% Intima-media thickness, Lower limbs
目的 研究2型糖尿病(T2DM)患者不同程度的下肢血管病变与血浆内脏脂肪素的关系.方法 选择泰安地区的T2DM患者112例,根据临床症状和下肢动脉彩色多普勒超声情况,分为单纯T2DM组42例,糖尿病合并轻度下肢动脉硬化(T2DM-MLAD)组38例和糖尿病合并重度下肢动脉硬化(T2DM-SLAD)组32例,另选取正常对照(NC)组40名.测定内脏脂肪素和其他相关临床指标,进行数据统计.结果 NC组与单纯T2DM组相比内脏脂肪素无统计学差异[分别(46.79±7.67)和(50.86±11.65)ng/ml,P>0.05],T2DM-MLAD组和T2DM-SLAD组内脏脂肪素[分别(58.75±13.52)和(67.21±16.6)ng/ml]均明显高于NC组和单纯T2DM组(P<0.01),T2DM-SLAD组又明显高于T2DM-MLAD组(P<0.01).Pearson相关分析表明,内脏脂肪素与WHR、FIns、HOMA-IR、下肢血管内膜中层厚度(IMT)、HbA1c呈正相关.踝肱指数(ABI)随糖尿病下肢动脉病变的出现与加重而逐渐降低.结论 内脏脂肪素与T2DM患者下肢血管病变程度明显相关,是下肢动脉硬化的危险因素.
目的 研究2型糖尿病(T2DM)患者不同程度的下肢血管病變與血漿內髒脂肪素的關繫.方法 選擇泰安地區的T2DM患者112例,根據臨床癥狀和下肢動脈綵色多普勒超聲情況,分為單純T2DM組42例,糖尿病閤併輕度下肢動脈硬化(T2DM-MLAD)組38例和糖尿病閤併重度下肢動脈硬化(T2DM-SLAD)組32例,另選取正常對照(NC)組40名.測定內髒脂肪素和其他相關臨床指標,進行數據統計.結果 NC組與單純T2DM組相比內髒脂肪素無統計學差異[分彆(46.79±7.67)和(50.86±11.65)ng/ml,P>0.05],T2DM-MLAD組和T2DM-SLAD組內髒脂肪素[分彆(58.75±13.52)和(67.21±16.6)ng/ml]均明顯高于NC組和單純T2DM組(P<0.01),T2DM-SLAD組又明顯高于T2DM-MLAD組(P<0.01).Pearson相關分析錶明,內髒脂肪素與WHR、FIns、HOMA-IR、下肢血管內膜中層厚度(IMT)、HbA1c呈正相關.踝肱指數(ABI)隨糖尿病下肢動脈病變的齣現與加重而逐漸降低.結論 內髒脂肪素與T2DM患者下肢血管病變程度明顯相關,是下肢動脈硬化的危險因素.
목적 연구2형당뇨병(T2DM)환자불동정도적하지혈관병변여혈장내장지방소적관계.방법 선택태안지구적T2DM환자112례,근거림상증상화하지동맥채색다보륵초성정황,분위단순T2DM조42례,당뇨병합병경도하지동맥경화(T2DM-MLAD)조38례화당뇨병합병중도하지동맥경화(T2DM-SLAD)조32례,령선취정상대조(NC)조40명.측정내장지방소화기타상관림상지표,진행수거통계.결과 NC조여단순T2DM조상비내장지방소무통계학차이[분별(46.79±7.67)화(50.86±11.65)ng/ml,P>0.05],T2DM-MLAD조화T2DM-SLAD조내장지방소[분별(58.75±13.52)화(67.21±16.6)ng/ml]균명현고우NC조화단순T2DM조(P<0.01),T2DM-SLAD조우명현고우T2DM-MLAD조(P<0.01).Pearson상관분석표명,내장지방소여WHR、FIns、HOMA-IR、하지혈관내막중층후도(IMT)、HbA1c정정상관.과굉지수(ABI)수당뇨병하지동맥병변적출현여가중이축점강저.결론 내장지방소여T2DM환자하지혈관병변정도명현상관,시하지동맥경화적위험인소.
Objective To study the relationship of the lowerlimb vascular disease with plasma visfatin in diabetics.MethodsThe study subjects included T2DM patients with mild lower limb atherosclerosis (n=38,T2DM-MLAD), with severe LA (n=32,T2DM-SLAD), without LA (n=42,T2DM) and healthy control (n=40,NC).ABI, serum visfatin,IMT of lower limbs by ultrosound and general clinical data were determined. Results Serum visfatin showed a similar level [(46.79±7.67)vs(50.86±11.65)ng/ml, P>0.05] between NC and T2DM groups,and a gradually lower levels from T2DM-SLAD to T2DM-MLAD to T2DM groups[(67.21±16.67)vs(58.75±13.52)vs(50.86±11.65)ng/ml respectively, intergroup comparison: all<0.05]. Serum visfatin was positively correlated with IMT of lower limbs, IR,HbA1c,FIns and WHR. Conclusion Serum visfatin is a risk factor for lower limb atherosclerosis and positively correlated with severity of lower limb atherosclerosis. Ankle-brachial index is decreasing along with the progressing of lower limb atherosclerosis.
