CAJ | 학술논문

目的研究食管癌组织中膜型基质金属蛋白酶-1(MT1-MMP)的表达及其临床意义.方法用免疫组织化学法检测54例食管癌患者的癌组织、正常组织MT1-MMP的表达.结果食管癌患者的癌组织MT1-MMP的阳性表达率(87.0%)与正常组织的阳性表达率(7.4%)比较差异有统计学意义(P＜0.01).MT1-MMP的表达程度随着肿瘤浸润深度的增加而加强(P＜0.01),MT1-MMP的表达程度与区域淋巴结转移、食管癌分化程度、食管癌术后3年转移和/或复发有关(P＜0.01).结论食管癌组织中MT1-MMP的表达与食管癌的肿瘤浸润深度、淋巴结转移情况、分化程度和预后有密切关系,MT1-MMP在食管癌的侵袭和转移中起着十分重要的作用.
목적 연구식관암조직중막형기질금속단백매-1(MT1-MMP)적표체급기림상의의.방법 용면역조직화학법검측54례식관암환자적암조직、정상조직MT1-MMP적표체.결과 식관암환자적암조직MT1-MMP적양성표체솔(87.0%)여정상조직적양성표체솔(7.4%)비교차이유통계학의의(P＜0.01).MT1-MMP적표체정도수착종류침윤심도적증가이가강(P＜0.01),MT1-MMP적표체정도여구역림파결전이、식관암분화정도、식관암술후3년전이화/혹복발유관(P＜0.01).결론 식관암조직중MT1-MMP적표체여식관암적종류침윤심도、림파결전이정황、분화정도화예후유밀절관계,MT1-MMP재식관암적침습화전이중기착십분중요적작용.
Objective To investigate the expression of membrane type 1 matrix metalloproteinase(MT1-MMP) in the esophageal carcinoma tissues and in normal periearcinomatous tissues and its clinical significance. Methods Immunohistochemistry was used to study the expression of MT1-MMP in esophageal carcinoma tissues and normal tissues in distance for 5-7 em from tumor. Results Among 54esophageal carcinoma specimens, the positive expression rate of MT1-MMP was 87.0%, while all of themwere expressed a small quantity in normal esophageal epithelial tissues, the expression in the esophageal carcinoma tissues was significantly higher than those in normal esophageal epithelial tissues (P ＜ 0.01 ).The degree of MT1-MMP expressions was associated with the depth of tumor invasion (P ＜ 0.01 ), the invasion of the lymph nodes(P ＜ 0.01 ) and the relapse and/or metastasis of the tumors for three years after surgery(P ＜0.01 ), and was also related to differentiation of tumor cells (P ＜ 0.01 ). Conclusions The expression of MT1-MMP in the esophageal carcinoma tissues is well associated with the depth of tumor invasion, the invasion of the lymph nodes, the differentiation of tumor cells and relapse and/or metastasis of the tumors for three years after surgery. MT1-MMP plays an important rote in the invasion and metastasis in the patients with esophageal carcinoma.