CAJ | 학술논문

目的研究化疗对恶性肿瘤患者卵巢功能的影响.方法收集34例女性恶性肿瘤存活者(病例组)与34例月经正常的女性健康者(对照组)l临床资料,调查病例组恶性肿瘤类型与治疗后月经情况,比较两组血清卵泡刺激素(FSH)、黄体牛成素(LH)、抗苗勒氏管激素(AMH)水平.结果 34例病例组中23例(67.6%)闭经,7例(20.6%)月经小规则,4例(11.8%)月经规则.病例组血清FSH、LH水平分别为(50.88±27.12)U/L、(36.87±27.86)U/L,对照组血清FSH、LH分别为(5.94±1.46)U/L、(4.13±1.78)U/L,两组血清FSH、LH水平差异有统计学意义(P均=0.000).病例组血清AMH显著低于对照组[(0.412±0.183)μg/L比(1.770±0.941)μg/L,P=0.000].病例组中月经规则的患者血清AMH水平显著低于对照组[(0.811±0.155)μg/L比(1.770±0.941)μg/L,P=0.000).病例组中血清FSH<10 U/L的患者,其AMH水平亦显著低于对照组[(0.581±0.225)μg/L比(1.770±0.941)μg/L,P=0.000].结论化疗对恶性肿瘤患者的卵巢功能有损害.血清AMH水平对恶性肿瘤患者卵巢储备功能下降的评估可能比FSH更敏感.
목적 연구화료대악성종류환자란소공능적영향.방법 수집34례녀성악성종류존활자(병례조)여34례월경정상적녀성건강자(대조조)l림상자료,조사병례조악성종류류형여치료후월경정황,비교량조혈청란포자격소(FSH)、황체우성소(LH)、항묘륵씨관격소(AMH)수평.결과 34례병례조중23례(67.6%)폐경,7례(20.6%)월경소규칙,4례(11.8%)월경규칙.병례조혈청FSH、LH수평분별위(50.88±27.12)U/L、(36.87±27.86)U/L,대조조혈청FSH、LH분별위(5.94±1.46)U/L、(4.13±1.78)U/L,량조혈청FSH、LH수평차이유통계학의의(P균=0.000).병례조혈청AMH현저저우대조조[(0.412±0.183)μg/L비(1.770±0.941)μg/L,P=0.000].병례조중월경규칙적환자혈청AMH수평현저저우대조조[(0.811±0.155)μg/L비(1.770±0.941)μg/L,P=0.000).병례조중혈청FSH<10 U/L적환자,기AMH수평역현저저우대조조[(0.581±0.225)μg/L비(1.770±0.941)μg/L,P=0.000].결론 화료대악성종류환자적란소공능유손해.혈청AMH수평대악성종류환자란소저비공능하강적평고가능비FSH경민감.
Objective To explore the impact of chemotherapy on ovarian function of patients with malignant tumor. Methods The clinical data of 34 malignant tumor survivors ( case group) and 34 healthy women with regular menstrual cycles (control group ) were collected. The malignant tumor types and menstrual cycle after treatment in the ease group were investigated. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and anti-Mullerian hormone (AMH) in two gnupe were compared. Results In the ease group including 34 patients, 23 ( 67.6% ) experienced amenorrhea, 7 ( 20. 6% ) irregular menstruation and 4 ( 11.8% ) regular menstruation. Serum FSH and LH levels were ( 50. 88 ±27. 12) U/L,(36.87±27.86) U/L respectively in the case group, while those were (5.94 ± 1.46) U/L and (4.13 ± 1.78) U/L in the control group. There were significant differences between two groups (all P= 0. 000). The serum level of AMH in the case group was significant lower than that in the control group [(0.412 ±0. 183 ) μg/L vs (1.770 ±0.941) μg/L, P =0.000]. Serum AMH level in patients with regular menstrations and those with serum FSH < 10 U/L in the case group were significantly lower than those in the control group [ ( 0. 811 ± 0. 155 )μg/L vs ( 1. 770 ± 0. 941 ) μg/L, (0. 581 ± 0. 225 ) μg,/L vs (1.770±0.941) μg/L, all P=0.000]. Cunclusions Chemotherapy may lead to the damage of ovarian function. The serum levels of AMH may be more sensitive than FSH to predict the descent of ovarian reserve in malignant tumor survivors.