CAJ | 학술논문

目的研究点时间尿蛋白与尿肌酐比值(P/Cr)是否可以代替24 h尿蛋白定量,用于子痫前期的诊断和病情监测.方法选取2010年1月至2011年12月间在浙江大学医学院附属邵逸夫医院产前检查的100例子痫前期孕妇和36例正常孕妇,对其晨尿P/Cr与24 h尿蛋白定量进行相关分析.采用ROC曲线分析确定晨尿P/Cr相对于24h尿蛋白定量为0.3及5 g的诊断界点.结果晨尿P/Cr与24h尿蛋白定量高度相关.应用ROC曲线计算晨尿P/Cr相对于24h尿蛋白定量0.3及5 g的诊断界点分别为0.34 g/g肌酐及2.08 g/g肌酐时敏感性和特异性最佳.结论点时间尿P/Cr可以替代24 h尿蛋白定量,是子痫前期的诊断、观察、随访工作中可靠、简便的实验方法.
목적 연구점시간뇨단백여뇨기항비치(P/Cr)시부가이대체24 h뇨단백정량,용우자간전기적진단화병정감측.방법 선취2010년1월지2011년12월간재절강대학의학원부속소일부의원산전검사적100례자간전기잉부화36례정상잉부,대기신뇨P/Cr여24 h뇨단백정량진행상관분석.채용ROC곡선분석학정신뇨P/Cr상대우24h뇨단백정량위0.3급5 g적진단계점.결과 신뇨P/Cr여24h뇨단백정량고도상관.응용ROC곡선계산신뇨P/Cr상대우24h뇨단백정량0.3급5 g적진단계점분별위0.34 g/g기항급2.08 g/g기항시민감성화특이성최가.결론 점시간뇨P/Cr가이체대24 h뇨단백정량,시자간전기적진단、관찰、수방공작중가고、간편적실험방법.
Objective To evaluate the clinical application of protein-to-creatinine ratio (P/Cr)in spot urine samples so as to check whether it can replace urine protein excretion in 24 h collections for the diagnosis and screening of preeclampsia.Methods The investigators selected 100 cases of pregnant women with preeclampsia and 36 cases of normal pregnant women examined at Sir Run Run Shaw Hospital over the last two years.The correlations between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections were analyzed.The cutoff values of P/Cr in first morning urine samples for screening preeclampsia of 0.3 g and 5 g in urinary protein excretion in 24 h collections were determined by a receiver operating characteristics (ROC) curve.Results A highly significant correlation existed between P/Cr in first morning urine samples and urinary protein excretion in 24 h collections.By the ROC curve analysis,the P/Cr of 0.34 g /g and 2.08 g/g in first morning urine samples represented the most appropriate threshold for detecting the urinary protein excretion of 0.3 g and 5 g in 24 h collections.Conclusion The P/Cr in spot urine samples can replace urinary protein excretion in 24 h collections.It is a simple and reliable tool of diagnosis and follow-up for preeclampsia.