CAJ | 학술논문

藻酸双酯钠具有抗凝、抗血栓以及调节血脂等作用,是一种新型的抗动脉粥样硬化药物.但它对糖尿病伴脂代谢异常血症的治疗作用还没有明确.本研究建立糖尿病伴脂代谢异常血症大鼠模型,初步探讨藻酸双酯钠对其血糖和血脂的调节作用.Wistar大鼠高脂饲料喂养1.5个月后尾静脉注射链脲佐菌素.建模成功后,灌胃给予藻酸双酯钠1个月,检测血中血糖、胰岛素和脂质浓度.结果显示,藻酸双酯钠治疗组与糖尿病对照组相比,血中甘油三酯、总胆固醇和低密度脂蛋白明显降低,高密度脂蛋白显著升高,藻酸双酯钠治疗后血糖和胰岛素浓度有所下降,而胰岛素敏感指数比糖尿病对照组明显提高.本研究提示,藻酸双酯钠可以改善糖尿病伴脂代谢异常血症大鼠血脂异常,并提高胰岛素敏感性.
조산쌍지납구유항응、항혈전이급조절혈지등작용,시일충신형적항동맥죽양경화약물.단타대당뇨병반지대사이상혈증적치료작용환몰유명학.본연구건립당뇨병반지대사이상혈증대서모형,초보탐토조산쌍지납대기혈당화혈지적조절작용.Wistar대서고지사료위양1.5개월후미정맥주사련뇨좌균소.건모성공후,관위급여조산쌍지납1개월,검측혈중혈당、이도소화지질농도.결과현시,조산쌍지납치료조여당뇨병대조조상비,혈중감유삼지、총담고순화저밀도지단백명현강저,고밀도지단백현저승고,조산쌍지납치료후혈당화이도소농도유소하강,이이도소민감지수비당뇨병대조조명현제고.본연구제시,조산쌍지납가이개선당뇨병반지대사이상혈증대서혈지이상,병제고이도소민감성.
Polysaccharide sulfate (PSS) is a new type of antiatherosclerotic medicine for its effects of anticoagulation, anti-thrombosis and modulation of dyslipidemia. However, it is still uncertain whether PSS could modulate the diabetic dyslipidemia or not. Here, the rat model of diabetic dyslipidemia was developed and the effects of PSS on glucose and lipid levels were investigated in this animal model. Wistar rats were iv injected with streptozotocin 20 mg·kg-1 after feeding with high fat diet for one and a half month. Then, rats received orally PSS (30, 90, and 180 mg·kg-1) for 1 month. After oral treatment with PSS (90 and 180 mg·kg-1) for 1 month, the levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) were significantly reduced and the level of high density lipoprotein-cholesterol (HDL-C) increased, compared with diabetic control rats. Moreover, PSS (30, 90, and 180 mg·kg-1) had a tendency to reduce glucose and insulin levels, and significantly increased insulin sensitivity index. Our results suggest that PSS could improve insulin sensitivity and relieve dyslipidemia in diabetic dyslipidemic rats.