CAJ | 학술논문

目的探讨妊娠糖尿病(GDM)患者脂联素与胰岛素抵抗(IR)的关系.方法检测40例GDM患者(GDM)、34例糖耐量正常(NGT)的孕妇作对照(NC)组的血清脂联素水平,同时以稳态模型HOMA-IR计算胰岛素抵抗指数.结果 (1)GDM组脂联素水平、HOMA-IR分别为7.83±1.57μg/L,3.57±1.27,对照组分别为9.36±1.41μg/L、2.98±1.03,两组比较差异有统计学意义.(2)GDM组多元线性逐步回归分析结果显示孕前BMI、脂联素是影响GDM患者IR的独立危险因素.结论 GDM患者血清脂联素减少与IR密切相关.
목적 탐토임신당뇨병(GDM)환자지련소여이도소저항(IR)적관계.방법 검측40례GDM환자(GDM)、34례당내량정상(NGT)적잉부작대조(NC)조적혈청지련소수평,동시이은태모형HOMA-IR계산이도소저항지수.결과 (1)GDM조지련소수평、HOMA-IR분별위7.83±1.57μg/L,3.57±1.27,대조조분별위9.36±1.41μg/L、2.98±1.03,량조비교차이유통계학의의.(2)GDM조다원선성축보회귀분석결과현시잉전BMI、지련소시영향GDM환자IR적독립위험인소.결론 GDM환자혈청지련소감소여IR밀절상관.
Objective To investigate the correlation of adiponectin level with insulin resistance in patients with gestational diabetes mellitus(GDM). Methods Adiponectin was determined in 40 patients with GDM and 34 control subjects. The insulin resistance index (HOMA-IR ) was calculated. Results (1)The meams of adiponectin and HOMA -IR were(7.83±1.57)μg/L and(3.57±1.27)respectively in GDM group and (9.36±1.41)μg/L and(2.98±1.03)respectively in the control subjects(all P<0.05).(2)A multiple linear stepwise regression analysis indicated that BMI and adiponectin were independent factors affecting HOMA-IR. Conclusions Adiponectin level is lower in GDM compared with control subjects,and adiponectin might play an important role in pathogenesis of insulin resistance.