CAJ | 학술논문

[目的]观察清醒血药浓度的丙泊酚(<1.5 μg/mL)联合氯诺昔康对全麻拔管期间不良反应的影响.[方法]将择期腹部手术40例随机分为Ⅰ、Ⅱ组,每组20例,两组患者均用咪唑安定+芬太尼+阿曲库胺+丙泊酚静脉诱导后气管插管,术中以吸入异氟烷、靶控输注丙泊酚、间断追加阿曲库胺和芬太尼维持.Ⅰ组患者于手术前及术毕前30 min分别静注氯诺昔康8 mg,并于手术结束前15 min将丙泊酚的血浆靶浓度调至1.2 μg/mL直至拔管后5 min;Ⅱ组给予等量生理盐水,并于手术结束前15 min停用丙泊酚.观察记录术毕前30 min时(T0)、缝皮时(T1)、手术结束时(T2)、拔管时(T3)、拔管后10 min(T4)等时点的平均动脉压(MAP)和心率(HR)的变化,以及苏醒期的躁动评分、拔管时间、苏醒时间、主诉疼痛时间.[结果]与T0比较,Ⅰ组在T3时MAP有升高(P<0.05)外,其余各时点MAP、HR均变化不大(P>0.05);Ⅱ组则在T1、T3、T4时,MAP和HR均有差异(P<0.05).Ⅰ组在T1、T3、T4时与Ⅱ组比较,MAP和HR差异均有显著性(P<0.05).Ⅰ组在苏醒期的躁动评分明显低于Ⅱ组(P<0.01),拔管时间、苏醒时间比较差异无显著性,术后主诉疼痛时间Ⅰ组明显比Ⅱ组延长(P<0.01).[结论]清醒血药浓度联合氯诺昔康在全麻患者苏醒期镇痛效果好,不延长苏醒时间,能减少不良反应,维持较平稳的血液循环.
[목적]관찰청성혈약농도적병박분(<1.5 μg/mL)연합록낙석강대전마발관기간불량반응적영향.[방법]장택기복부수술40례수궤분위Ⅰ、Ⅱ조,매조20례,량조환자균용미서안정+분태니+아곡고알+병박분정맥유도후기관삽관,술중이흡입이불완、파공수주병박분、간단추가아곡고알화분태니유지.Ⅰ조환자우수술전급술필전30 min분별정주록낙석강8 mg,병우수술결속전15 min장병박분적혈장파농도조지1.2 μg/mL직지발관후5 min;Ⅱ조급여등량생리염수,병우수술결속전15 min정용병박분.관찰기록술필전30 min시(T0)、봉피시(T1)、수술결속시(T2)、발관시(T3)、발관후10 min(T4)등시점적평균동맥압(MAP)화심솔(HR)적변화,이급소성기적조동평분、발관시간、소성시간、주소동통시간.[결과]여T0비교,Ⅰ조재T3시MAP유승고(P<0.05)외,기여각시점MAP、HR균변화불대(P>0.05);Ⅱ조칙재T1、T3、T4시,MAP화HR균유차이(P<0.05).Ⅰ조재T1、T3、T4시여Ⅱ조비교,MAP화HR차이균유현저성(P<0.05).Ⅰ조재소성기적조동평분명현저우Ⅱ조(P<0.01),발관시간、소성시간비교차이무현저성,술후주소동통시간Ⅰ조명현비Ⅱ조연장(P<0.01).[결론]청성혈약농도연합록낙석강재전마환자소성기진통효과호,불연장소성시간,능감소불량반응,유지교평은적혈액순배.
[Objective]To investigate the effect of propofol with conscious plasma concentration combined with lornoxicam on adverse reaction during extubation after general anesthesia. [Methods] Forty patients undergoing abdominal surgery were assigned randomly into two groups with 20 cases for each. All patients were induced with propofol combined with midazolam, fentanyl and atracurium, then maintained with isoflurane, propofol, atracurium and fentanyl. Patients in groupⅠreceived lornoxicam 8mg intravenously for 30min before surgery and the end of surgery separately. Before the end of surgery, plasma concentration of propofol infused by TCI was set to 1.2μg/mL until 5min after extubation. Those in group Ⅱ were given saline and propofol was stopped 15min before the end of surgery. All the data including MAP, HR at 30min before the end of operation(T0), suturation(T1), the end of operation(T2), extubation(T3), 10min after extubation(T4), emergence agitation scores, time to extubation, time to wake-up and complaining of pain were assessed. [Results] MAP increased at T3(P<0.05) in groupⅠ. In group Ⅱ, both MAP and HR increased at T1, T3 and T4 (P<0.05). There were significant differences at T1, T3, T4 between two groups (P<0.05). Emergence agitation scores in group Ⅰwere significantly lower than those in groupⅡ(P<0.01). Time to complaining of pain in groupⅠwas significantly longer than that in groupⅡ(P<0.01). No statistical difference was found in time to extubation and wake-up. [Conclusion] Propofol with conscious plasma concentration combined with lornoxicam can provide efficient pain relief during emergence after general anesthesia, which can produce hemodynamic stability, few adverse reactions and no influence on wake-up time.