CAJ | 학술논문

目的探讨血清白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)浓度的测定在病毒性肝炎患者中的意义.方法采用放射免疫分析法分别检测健康对照组和病毒性肝炎组血清IL-6和TNF-α的浓度,并分别检测其HBV DNA含量.结果病毒性肝炎患者的IL-6和TNF-α的浓度水平显著高于健康对照组,差异有统计学意义(P<0.01);肝炎后肝硬化组显著高于慢性乙型肝炎组,差异有统计学意义(P<0.01);HBV DNA阳性组显著高于HBV DNA阴性组,差异有统计学意义(P<0.01).结论血清IL-6和TNF-α的测定对病毒性肝炎患者机体的免疫损伤状况进行有效的反映,对判断患者病情预测和预后有一定的现实意义.
목적 탐토혈청백세포개소-6(IL-6)화종류배사인자(TNF-α)농도적측정재병독성간염환자중적의의.방법 채용방사면역분석법분별검측건강대조조화병독성간염조혈청IL-6화TNF-α적농도,병분별검측기HBV DNA함량.결과 병독성간염환자적IL-6화TNF-α적농도수평현저고우건강대조조,차이유통계학의의(P<0.01);간염후간경화조현저고우만성을형간염조,차이유통계학의의(P<0.01);HBV DNA양성조현저고우HBV DNA음성조,차이유통계학의의(P<0.01).결론 혈청IL-6화TNF-α적측정대병독성간염환자궤체적면역손상상황진행유효적반영,대판단환자병정예측화예후유일정적현실의의.
Objective To explore the significance of serum IL-6 and TNF-α concentrations in patients with hepatitis.Methods To detect and measure, by radiommunassay(RIA), the concentrations of the serum IL-6 and TNF-αand their HBV DNA of the normal control group and the group with hepatitis.Results The concentrations of IL 6 and TNF of the patients with heptitis were significantly higher than those of the control group(P<0.01), and liver cirrhosis group was significantly higher than that of chronic hepatitis B group(P<0.01),HBV DNA positive group was significantly higher than that of HBV DNA negative(P<0.01).Conclusion The detect to the serum IL-6 and TNF a is able to reflect effectively on the immune status of the patients with hepatitis and has some practical significance in judging and predicting the prognosis of the patients.