CAJ | 학술논문

采用共沉淀法制备出Fe3O4磁性纳米粒子,经油酸表面处理后分散在碘化油中,制成Fe3O4/碘化油磁流体.考察了磁流体的磁性能、稳定性以及产热性能,并通过动物实验研究了其体内产热性能和热疗安全性.结果显示,制备的Fe3O4/碘化油磁流体具有超顺磁性和良好的稳定性,在交变磁场中可产生很强的热效应,其SAR值可达到121W/g.此外,该磁流体可在交变磁场中产生足够的热量使肿瘤升温至热疗温度,同时证明其具有良好的靶向性和热安全性.
채용공침정법제비출Fe3O4자성납미입자,경유산표면처리후분산재전화유중,제성Fe3O4/전화유자류체.고찰료자류체적자성능、은정성이급산열성능,병통과동물실험연구료기체내산열성능화열료안전성.결과현시,제비적Fe3O4/전화유자류체구유초순자성화량호적은정성,재교변자장중가산생흔강적열효응,기SAR치가체도121W/g.차외,해자류체가재교변자장중산생족구적열량사종류승온지열료온도,동시증명기구유량호적파향성화열안전성.
After treated with oleic acid (OA), the magnetite particles prepared by co-precipitation were dispersed in iodinated oil and then magnetite/iodized oil dispersion were obtained. The magnetic properties, stability and heating property of the dispersion were studied. Moreover, the vivo experiment was employed to research the heating ability and hyperthermia security of the dispersion. The experiment results demonstrated that the magnetite/iodized oil dispersion was of superparamagnetism and stability and could produce strong heat effect in the alternating magnetic field. The Specific Absorption Rate (SAR) value was calculated to be 121W/g. Furthermore, the results of heating experiment in vivo demonstrated that the heat generated by the magnetite/iodized oil dispersion could heat tumor to the hyperthermia temperature. The heat tumor-targeting property and heat security of the magnetite/iodized oil dispersion was confirmed.