CAJ | 학술논문

目的调查广州市健康人群的血尿酸水平,建立本地区健康成人血尿酸的参考值.方法采用尿酸酶-过氧化物酶耦联法检测2 451例健康成人血尿酸,其中男性1 313例,女性1 138例.结果健康男性血尿酸均值为(335.90±66.75)μmol/L,女性血尿酸均值为(244.49±56.33)μmol/L,男性各年龄组尿酸水平明显高于女性(P<0.05).男性的血尿酸水平随年龄的增加差异无统计学意义(P>0.05);女性的血尿酸水平随年龄的增加呈波段性增加,20～岁年龄组与30～岁年龄组处于较低水平,两年龄组差异无统计学意义(P>0.05);而40～岁年龄组显著高于40岁以下的各年龄组(P<0.05),但也显著低于50岁以上各年龄组(P<0.05);50岁以上各年龄组血尿酸有逐渐增加的趋势,但差异无统计学意义(P>0.05).本次调查显示,男性与女性中青年及女性老年、老年前期的血尿酸参考值上限依次为469.40、349.85、375.68 μmol/L,参考值下限依次为202.40、127.61、170.44 μmol/L.结论女性的不同年龄之间存在明显差异,应相应制定不同的尿酸参考范围;同时,各地区的血尿酸的平均水平也不尽相同,有必要建立本地区的参考值.
목적 조사엄주시건강인군적혈뇨산수평,건립본지구건강성인혈뇨산적삼고치.방법 채용뇨산매-과양화물매우련법검측2 451례건강성인혈뇨산,기중남성1 313례,녀성1 138례.결과 건강남성혈뇨산균치위(335.90±66.75)μmol/L,녀성혈뇨산균치위(244.49±56.33)μmol/L,남성각년령조뇨산수평명현고우녀성(P<0.05).남성적혈뇨산수평수년령적증가차이무통계학의의(P>0.05);녀성적혈뇨산수평수년령적증가정파단성증가,20～세년령조여30～세년령조처우교저수평,량년령조차이무통계학의의(P>0.05);이40～세년령조현저고우40세이하적각년령조(P<0.05),단야현저저우50세이상각년령조(P<0.05);50세이상각년령조혈뇨산유축점증가적추세,단차이무통계학의의(P>0.05).본차조사현시,남성여녀성중청년급녀성노년、노년전기적혈뇨산삼고치상한의차위469.40、349.85、375.68 μmol/L,삼고치하한의차위202.40、127.61、170.44 μmol/L.결론 녀성적불동년령지간존재명현차이,응상응제정불동적뇨산삼고범위;동시,각지구적혈뇨산적평균수평야불진상동,유필요건립본지구적삼고치.
Objective To investigate seum level of uric acid in healthy adults in Guangzhou City, and eatablish the reference range of serum uric acid in Guangzhou area.Methods Uricase-peroxydase coupling method was adopted to measure serum level of uric acid in 2 451 healthy adults (1 313 males, 1 138 females).Results Mean value (μmol/L) of serum uric acid was significant higher in healthy males than that in healthy females (335.90±66.75 vs 244.49±56.33,P<0.05). The level of serum uric acid in male group kept no chage with increase of age (P>0.05), whereas the level of serum uric acid in female group showed wave banded increase with increase of age: there was no statistical difference between 20- age group and 30- age group, both keeping a lower level; the level of serum uric acid in 40- age group was significant higher than that in <40 year age groups, but obviously lower than that in >50 year age groups (P<0.05); the level of serum uric acid in >50 year age groups had a increasing tendency, but the difference was not significant (P>0.05). The upper limit of reference range (μmol/L) was 469.40, 349.85 and 375.68 in youngster group, female elder group and female presenium group, respectively; the lower limit was respectively 202.40, 127.61 and 170.44.Conclusion There is difference in level of serum uric acid between male and females, different female age groups. Therefore, it is necessary to establish different reference range of serum uric acid; meanwhile, the reference range in local area should be eatablished because of different mean value in different area.