国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2009年
6期
461-464
,共4页
Th17细胞%IL-17%自身免疫性疾病
Th17細胞%IL-17%自身免疫性疾病
Th17세포%IL-17%자신면역성질병
Th17 cells%IL-17%Autoimmune diseases
Th17细胞是近年发现的不同于Th1细胞和Th2细胞的新型CD4+T细胞亚群.活化的Th17细胞可分泌IL-17、肿瘤坏死因子-α(TNF-α)、IL-6、粒-单核细胞集落刺激因子(GM-CSF)等多种促炎症因子,Th17细胞不适当的激活与多种自身免疫性疾病和过敏性疾病密切相关.在体内阻断Th17细胞的分化、扩增及其相关细胞因子可预防、延缓或阻止自身免疫性疾病的发生、发展.
Th17細胞是近年髮現的不同于Th1細胞和Th2細胞的新型CD4+T細胞亞群.活化的Th17細胞可分泌IL-17、腫瘤壞死因子-α(TNF-α)、IL-6、粒-單覈細胞集落刺激因子(GM-CSF)等多種促炎癥因子,Th17細胞不適噹的激活與多種自身免疫性疾病和過敏性疾病密切相關.在體內阻斷Th17細胞的分化、擴增及其相關細胞因子可預防、延緩或阻止自身免疫性疾病的髮生、髮展.
Th17세포시근년발현적불동우Th1세포화Th2세포적신형CD4+T세포아군.활화적Th17세포가분비IL-17、종류배사인자-α(TNF-α)、IL-6、립-단핵세포집락자격인자(GM-CSF)등다충촉염증인자,Th17세포불괄당적격활여다충자신면역성질병화과민성질병밀절상관.재체내조단Th17세포적분화、확증급기상관세포인자가예방、연완혹조지자신면역성질병적발생、발전.
Resent studies indicated that IL-17-producing Th17 cells subset is a new lineage of CD4+ + effector T helper cells distinct from the traditional Thl and Th2 cell. Activated Th17 cell subset has crucial roles in auto-immune and allergic disorders. Inhibiting the differentiation and proliferation of Th17 cells subsets, as well as its major effect factor may prevent or delay the development of autoimmune diseases.
