CAJ | 학술논문

目的探讨1-溴丙烷(1-BP)对职业接触女工健康的影响.方法对4个1-BP生严工厂进行职业卫生现场调查.按1:1比例选取年龄配对的接触组和对照组女工各71人.作业环境中1-BP的监测运用直读式检气管和个体采样器测定.对工人进行问卷调查、神经行为学组表测试、胫神经和腓神经电生理检查、振动觉检查、血常规、血生化和激素水平检查.结果作业环境中1-BP的浓度为0～402.40 mg/m3(平均32.19 mg/m3),工人时间加权平均接触浓度(TWA-8 h)为0.35～535.19 mg/m3(平均14.08 mg/m3).与对照组相比,1-BP接触工人的运动神经传导速度[(44.8±8.7)m/s]和感觉神经传导速度[(45.5±4.9)m/s]下降,远端潜伏期延长[(7.5±2.1)ms],足趾振动觉降低[双足音叉振动延迟时间分别为(6.2±4.4)和(5.7±4.4)s],神经行为学POMS量表中愤怒情绪得分增高(21.0±5.5),紧张、疲劳、迷茫情绪得分降低(7.8±5.5、5.6±4.1、6.1±3.8),差异均有统计学意义(P＜0.05).与对照组比较,接触组白细胞[(5.6±2.17)×103/μl]、红细胞[(3.9±0.4)×106/μl]、血红蛋白[(121.1±14.5)g/L]和肌酸磷酸激酶[(82.0±27.5)IU/L均明显降低,差异有统计学意义(P＜0.05),血清总蛋白[(8.0±0.5)g/dl]、乳酸脱氢酶[(335.2±356.6)IU/L]、促甲状腺激素[(3.6±2.3)μIU/ml]和尿促卵泡素水平[(18.7±24.4)mIU/ml]明显上升,差异有统计学意义(P＜0.05).结论 1-BP接触可能影响外周神经和中枢神经系统,并引起血液及生化学指标的异常.
목적 탐토1-추병완(1-BP)대직업접촉녀공건강적영향.방법 대4개1-BP생엄공엄진행직업위생현장조사.안1:1비례선취년령배대적접촉조화대조조녀공각71인.작업배경중1-BP적감측운용직독식검기관화개체채양기측정.대공인진행문권조사、신경행위학조표측시、경신경화비신경전생리검사、진동각검사、혈상규、혈생화화격소수평검사.결과 작업배경중1-BP적농도위0～402.40 mg/m3(평균32.19 mg/m3),공인시간가권평균접촉농도(TWA-8 h)위0.35～535.19 mg/m3(평균14.08 mg/m3).여대조조상비,1-BP접촉공인적운동신경전도속도[(44.8±8.7)m/s]화감각신경전도속도[(45.5±4.9)m/s]하강,원단잠복기연장[(7.5±2.1)ms],족지진동각강저[쌍족음차진동연지시간분별위(6.2±4.4)화(5.7±4.4)s],신경행위학POMS량표중분노정서득분증고(21.0±5.5),긴장、피로、미망정서득분강저(7.8±5.5、5.6±4.1、6.1±3.8),차이균유통계학의의(P＜0.05).여대조조비교,접촉조백세포[(5.6±2.17)×103/μl]、홍세포[(3.9±0.4)×106/μl]、혈홍단백[(121.1±14.5)g/L]화기산린산격매[(82.0±27.5)IU/L균명현강저,차이유통계학의의(P＜0.05),혈청총단백[(8.0±0.5)g/dl]、유산탈경매[(335.2±356.6)IU/L]、촉갑상선격소[(3.6±2.3)μIU/ml]화뇨촉란포소수평[(18.7±24.4)mIU/ml]명현상승,차이유통계학의의(P＜0.05).결론 1-BP접촉가능영향외주신경화중추신경계통,병인기혈액급생화학지표적이상.
Objective To investigate the health effects of 1-bromopropane(1-BP)on female exposed workers.Methods Four 1-BP manufacturing plants were investigated.Workers were interviewed with questionnaire and examined with neurobehavioral core test battery.nerve conduction velocity tests of nervus tibialis and nervus suralis.vibration sensation test,hematological and biochemical tests.Ambient 1-BP concentration was measured with detection tube.and time-weighed average levels of individual workers were estimated with passive samplers.Results 1-BP concentration in the plants ranged from 0 to 402.40 mg/m3(Geomean 32.19mg/m3).Time.weighted average exposure levels(TWA-8 h)ranged from 0.35 to 535.19 mg/m3(Geomean 14.08mg/m3).Compared with the control group.1-BP exposed workors showed reduced motor nerve conduction ve locity[(44.8±8.7)m/s]and sensory nerve conduction velocity[(45.5±4.9)m/s],prolonged distal latency[(7.5±2.1)ms],reduced toe vibration perception,and altered neurobehavior parameters(POMS vigor,tension,anxiety,confusion)significantly(P＜0.05).As to hematological and biochemical indicators,the exposed workers showed decreased white blood cell count[(5.6±2.17)×103/μl],red blood cell count[(3.9±0.4)×106/μl,hemoglobin [(121.1±14.5)g/L]and creatine kinase[(82.0±27.5)IU/L](P＜0.05),and increased serum total protein(8.0±0.5 g/d1),lactate dehydrogenase[(335.2±356.6)IU/L],thyroid-stimulating hormone[(3.6±2.3)μIU/ml] and follicle-stimulating hormone level(18.7±24.4mIU/ml)(P＜0.05).Conclusion 1-BP exposurre may affect peripheral nerves and central nervous system.and lead to abnormal hematological and biomedical indicators.