CAJ | 학술논문

Wnt信号传导通路在胚胎发育和中枢神经系统形成中起关键作用,调控细胞的生长、迁移和分化.它主要由经典Wnt/β-连接蛋白信号途径和非经典的Wnt信号途径组成.近年来的研究发现,它是一条与肿瘤有密切关系的信号转导通路,其在肺癌发生、发展中所起的重要作用也逐渐被揭示.
Wnt신호전도통로재배태발육화중추신경계통형성중기관건작용,조공세포적생장、천이화분화.타주요유경전Wnt/β-련접단백신호도경화비경전적Wnt신호도경조성.근년래적연구발현,타시일조여종류유밀절관계적신호전도통로,기재폐암발생、발전중소기적중요작용야축점피게시.
Wnt single transduction pathway plays a key role in fetal development and central nervous system formation, and regulates cell growth,migration and differentiation. It mainly consist of the classical Wnt βcatenin pathway and the non classical pathway. Recent researches reveal that the Wnt pathway is associated with cancer, and its important role in lung cancer genesis and development has been revealed gradually.