中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
24期
25-27
,共3页
万永红%张志聪%李艳霞%李霞%汪晓兰%李尚文
萬永紅%張誌聰%李豔霞%李霞%汪曉蘭%李尚文
만영홍%장지총%리염하%리하%왕효란%리상문
乳腺肿瘤%紫杉酚%顺铂
乳腺腫瘤%紫杉酚%順鉑
유선종류%자삼분%순박
Breast neoplasms%Paclitaxel%Cisplatin
目的 评价国产紫杉醇联合顺铂在转移性乳腺癌中的疗效和不良反应.方法 转移性乳腺癌患者53例,其中绝经前22例,绝经后31例；内脏器官转移37例,非内脏器官转移16例.患者均采用紫杉醇加顺铂方案化疗,国产紫杉醇175 mg/m2第1天静脉滴注,顺铂80 mg/m2第1～3天静脉滴注,21 ～ 28 d为1个周期,连续治疗2～6个周期后评价疗效.结果 患者接受了中位为4(2～6)个周期的化疗,总有效率为56.60％(30/53),疾病控制率为81.13％(43/53).内脏器宫转移患者与非内脏器官转移患者、绝经前患者与绝经后患者的总有效率比较差异均无统计学意义[56.76％(21/37)比56.25％(9/16)、59.09％ (13/22)比54.84％( 17/31),P＞ 0.05].全部患者中位生存时间为18.8(12～27)个月,1、2年生存率分别为56.60％( 30/53)和30.19％(16/53).主要不良反应为胃肠道反应、脱发和骨髓抑制,神经及心脏毒性发生率较低,分别为15.09％(8/53)和7.55％ (4/53).结论 国产紫杉醇联合顺铂治疗转移性乳腺癌有很好的疗效,值得在临床中推广应用.
目的 評價國產紫杉醇聯閤順鉑在轉移性乳腺癌中的療效和不良反應.方法 轉移性乳腺癌患者53例,其中絕經前22例,絕經後31例；內髒器官轉移37例,非內髒器官轉移16例.患者均採用紫杉醇加順鉑方案化療,國產紫杉醇175 mg/m2第1天靜脈滴註,順鉑80 mg/m2第1～3天靜脈滴註,21 ～ 28 d為1箇週期,連續治療2～6箇週期後評價療效.結果 患者接受瞭中位為4(2～6)箇週期的化療,總有效率為56.60％(30/53),疾病控製率為81.13％(43/53).內髒器宮轉移患者與非內髒器官轉移患者、絕經前患者與絕經後患者的總有效率比較差異均無統計學意義[56.76％(21/37)比56.25％(9/16)、59.09％ (13/22)比54.84％( 17/31),P＞ 0.05].全部患者中位生存時間為18.8(12～27)箇月,1、2年生存率分彆為56.60％( 30/53)和30.19％(16/53).主要不良反應為胃腸道反應、脫髮和骨髓抑製,神經及心髒毒性髮生率較低,分彆為15.09％(8/53)和7.55％ (4/53).結論 國產紫杉醇聯閤順鉑治療轉移性乳腺癌有很好的療效,值得在臨床中推廣應用.
목적 평개국산자삼순연합순박재전이성유선암중적료효화불량반응.방법 전이성유선암환자53례,기중절경전22례,절경후31례；내장기관전이37례,비내장기관전이16례.환자균채용자삼순가순박방안화료,국산자삼순175 mg/m2제1천정맥적주,순박80 mg/m2제1～3천정맥적주,21 ～ 28 d위1개주기,련속치료2～6개주기후평개료효.결과 환자접수료중위위4(2～6)개주기적화료,총유효솔위56.60％(30/53),질병공제솔위81.13％(43/53).내장기궁전이환자여비내장기관전이환자、절경전환자여절경후환자적총유효솔비교차이균무통계학의의[56.76％(21/37)비56.25％(9/16)、59.09％ (13/22)비54.84％( 17/31),P＞ 0.05].전부환자중위생존시간위18.8(12～27)개월,1、2년생존솔분별위56.60％( 30/53)화30.19％(16/53).주요불량반응위위장도반응、탈발화골수억제,신경급심장독성발생솔교저,분별위15.09％(8/53)화7.55％ (4/53).결론 국산자삼순연합순박치료전이성유선암유흔호적료효,치득재림상중추엄응용.
Objective To evaluate the therapeutical effect and toxicity of home-made paclitaxel and cisplatin combination in metastatic breast cancer.Methods Home-made paclitaxel 175 mg/m2,d1 intravenous drip,cisplatin 80 mg/m2,d1-3 intravenous drip,21-28 d was one cycle,all patients continuous course treatment for 2-6 cycles,then the effect was evaluated.Results All the patients received meso-cycle were 4 (2-6) cycles chemotherapy.The total effective rate was 56.60％ (30/53),disease control rate was 81.13％(43/53 ).The rates of internal organ metastasis and non-internal organ metastasis,before menopause and after menopause had no significant difference [56.76％ (21/37) vs.56.25％ (9/16),59.09％ (13/22) vs.54.84％ ( 17/31 ),P ＞ 0.05 ].The median existence time for all the patients was 18.8 ( 12-27 ) months.The survival rate was 56.60％ (30/53) and 30.19％ (16/53) for 1 and 2 years respectively.The major toxieities were gastrointestinal reaction,alopeoia and myelosuppression,the rates of nerve and heart toxicities were less,15.09％ (8/53) and 7.55％ (4/53) respectively.Conclusion The therapeutic effect of home-made paclitaxel and cisplatin combination in metastatic breast cancer is good,it is to be worth to spread in clinic.
