CAJ | 학술논문

目的探讨特发性黄斑裂孔患者手术前后光感受器细胞层内外节的改变特征.方法回顾性病例系列研究.收集32例(32只眼)确诊并接受手术治疗的特发性黄斑裂孔患者的临床资料进行回顾性分析,同时对其手术前后的高分辨率频域相干光断层扫描(OCT)图像进行对比研究.患者手术前与后logMAR视力和光感受器细胞层内外节被破坏区域直径比较,采用配对t检验;手术前黄斑裂孔直径和光感受器细胞层内外节被破坏区域直径与术后logMAR视力比较,采用Bivariate过程的Pearson相关分析法.结果 32例(32只眼)患者的logMAR视力为0.40～2.00,平均1.16±0.46;黄斑裂孔直径332～1568 μm,平均(859.7±292.0)μm;光感受器细胞层内外节被破坏区域直径867～3444 μm,平均(1965.1±584.1)μm.手术后25只眼(78.1%)黄斑裂孔闭合,logMAR视力为0.30～2.00,平均0.89±0.46;光感受器细胞层内外节被破坏区域直径153～2546 μm,平均(1350.4±642.6)μm;手术后患者病变修复和视力改善情况与手术前logMAR视力(t=3.384)和光感受器细胞层内外节被破坏区域直径(t=6.360)比较,差异均有统计学意义(P<0.05).患者手术前的黄斑裂孔直径(r=0.583)和光感受器细胞层内外节被破坏区域直径(r=0.416)与术后logMAR视力呈正相关(P<0.05).结论患者术前黄斑裂孔直径和光感受器细胞层内外节被破坏区域直径与术后视力呈正相关.接受手术治疗的患者其光感受器细胞层内外节被破坏区域明显缩小.(中华眼科杂志,2011,47:504-507)
목적 탐토특발성황반렬공환자수술전후광감수기세포층내외절적개변특정.방법 회고성병례계렬연구.수집32례(32지안)학진병접수수술치료적특발성황반렬공환자적림상자료진행회고성분석,동시대기수술전후적고분변솔빈역상간광단층소묘(OCT)도상진행대비연구.환자수술전여후logMAR시력화광감수기세포층내외절피파배구역직경비교,채용배대t검험;수술전황반렬공직경화광감수기세포층내외절피파배구역직경여술후logMAR시력비교,채용Bivariate과정적Pearson상관분석법.결과 32례(32지안)환자적logMAR시력위0.40～2.00,평균1.16±0.46;황반렬공직경332～1568 μm,평균(859.7±292.0)μm;광감수기세포층내외절피파배구역직경867～3444 μm,평균(1965.1±584.1)μm.수술후25지안(78.1%)황반렬공폐합,logMAR시력위0.30～2.00,평균0.89±0.46;광감수기세포층내외절피파배구역직경153～2546 μm,평균(1350.4±642.6)μm;수술후환자병변수복화시력개선정황여수술전logMAR시력(t=3.384)화광감수기세포층내외절피파배구역직경(t=6.360)비교,차이균유통계학의의(P<0.05).환자수술전적황반렬공직경(r=0.583)화광감수기세포층내외절피파배구역직경(r=0.416)여술후logMAR시력정정상관(P<0.05).결론 환자술전황반렬공직경화광감수기세포층내외절피파배구역직경여술후시력정정상관.접수수술치료적환자기광감수기세포층내외절피파배구역명현축소.(중화안과잡지,2011,47:504-507)
Objective To evaluate the findings of spectral domain optical coherence tomography (SD-OCT) in patients with idiopathic macular hole (IMH). Methods It was a retrospective case series study. Pre- and post-operative data from patients with IMH during 14 months were analyzed retrospectively. The main outcome data included logarithm of the minimal angle of resolution (logMAR) and SD-OCT findings, including the size of the IMH and the disruption of the boundary line between inner segments (IS) and outer segments (OS) of the photoreceptors. The data were analyzed using the statistical software SPSS14.0. The correlation among various data was analyzed by Bivariate correlation. The pre-and post-operative data were compared by paired-samples t-tests. Results Thirty two eyes of 32 patients were studied. The mean logMAR was 1.16±0.46 (ranged from 0.40 to 2.00), the mean diameter of macular hole was (859.7±292.0) μm (ranged from 332 to 1568 μm).The mean diameter of IS/OS disruption was (1965.1±584.1) μm (ranged from 867 to 3444 μm). In eyes after surgery, the mean logMAR was 0.89±0.46 (ranged from 0.30 to 2.00), the mean diameter of the IS/OS disruption was (1350.4±642.6) μm (ranged from 153 to 2546 μm), both were decreased significantly as compare with the preoperative data(t=3.384,6.360;P<0.05). Preoperative diameter of macular hole(r=0.583) and IS/OS disruption(r=0.416) were correlated significantly with postoperative logMAR(P<0.05). Conclusions Preoperative diameter of macular hole and IS/OS disruption play the main role in vision prognosis. The IS/OS disruption is decreased significantly after the operation.