CAJ | 학술논문

背景:细菌形成生物膜后耐药性极强,可以逃避宿主的免疫作用,在感染部位难以彻底清除,是临床上难治性感染的重要原因之一.目的:文章综述了细菌生物膜耐药机制的研究进展,以便寻找有效控制手段,指导临床合理用药和新药开发.方法:应用计算机检索CNKI和PubMed数据库中1998-01/2008 12关于细菌生物膜耐药机制的文章,在标题和摘要中以"生物膜;耐药性;细菌;感染"或"biofilm:Drug resistance;bacteria;Infection"为检索词进行检索.选择文章内容与细菌生物膜感染相关,同一领域文献则选择近期发表或发表在权威杂志文章.初检得到285篇文献,根据纳入标准选择23篇文章进行综述.结果与结论:对细菌生物膜形成机制的了解,有利于更合理选择抗生素,有效的控制好临床感染.细菌形成生物膜后耐药性明显增加,耐药机制尚未完全清楚,生物膜的ESS物理屏障作用、特殊微环境、细菌密度感应系统等在耐药形成中都发挥一定作用,而且可能是多因素协同作用.通过该方面的机制研究指导临床用药和新药开发.
배경:세균형성생물막후내약성겁강,가이도피숙주적면역작용,재감염부위난이철저청제,시림상상난치성감염적중요원인지일.목적:문장종술료세균생물막내약궤제적연구진전,이편심조유효공제수단,지도림상합리용약화신약개발.방법:응용계산궤검색CNKI화PubMed수거고중1998-01/2008 12관우세균생물막내약궤제적문장,재표제화적요중이"생물막;내약성;세균;감염"혹"biofilm:Drug resistance;bacteria;Infection"위검색사진행검색.선택문장내용여세균생물막감염상관,동일영역문헌칙선택근기발표혹발표재권위잡지문장.초검득도285편문헌,근거납입표준선택23편문장진행종술.결과여결론:대세균생물막형성궤제적료해,유리우경합리선택항생소,유효적공제호림상감염.세균형성생물막후내약성명현증가,내약궤제상미완전청초,생물막적ESS물리병장작용、특수미배경、세균밀도감응계통등재내약형성중도발휘일정작용,이차가능시다인소협동작용.통과해방면적궤제연구지도림상용약화신약개발.
BACKGROUND: After the formation of biofilm, drug resistance of bacteria was strong, and it could evade the host immune function and be difficultly eradicated at the site of infection. Therefore, it was one of important reasons of refractory infection in clinic.OBJECTIVE: To review the research and progress of drug-resistant mechanisms of bacterial biofilm in order to find effective means and guide clinical use of drugs and drug discovery.METHODS: Articles about drug-resistant mechanism of bacterial biofilm were retrieved from CNKI and PubMed with the key words of "iofilm; drug resistance; bacteria; infection" in both Chinese and English from January 1998 and December 2008. Articles in the same circle published in the authoritative journals or recently published were included. Among 285 articles, 23 were included in the final analysis.RESULTS AND CONCLUSION: Understanding of the mechanisms of the bacterial biofilm formation helped us Choose a more rational use of antibiotics and effective control over a good clinical infection. After the bacterium biofilm forming, the bacteria biofilm drug resistance increased obviously, but the mechanisms were not yet entirely clear, the action of biofilm ESS physical barrier, special micro-environment, bacterial quorum sensing systems and so on, all played roles in the resistance, they might be multi-factorial synergistic effect. The study of mechanism provides evidences for clinical medicine and drug discovery.