CAJ | 학술논문

B7H1是近年来发现的B7家族的一个新成员.它与活化T细胞表面表达的PD-1受体结合后,具有抑制T细胞增生和产生细胞因子的作用.研究发现B7H1在外周耐受、自身免疫病、慢性感染等疾病中具有负性调节作用.近期发现许多肿瘤细胞表面亦可大量B7H1分子表达,参与肿瘤的免疫逃逸.阻断B7H1/PD-1通路可能有助于自身免疫病及恶性肿瘤的治疗.
B7H1시근년래발현적B7가족적일개신성원.타여활화T세포표면표체적PD-1수체결합후,구유억제T세포증생화산생세포인자적작용.연구발현B7H1재외주내수、자신면역병、만성감염등질병중구유부성조절작용.근기발현허다종류세포표면역가대량B7H1분자표체,삼여종류적면역도일.조단B7H1/PD-1통로가능유조우자신면역병급악성종류적치료.
B7H1 is a recently described B7 family member.Ligation of PD-1 receptors with B7hl on the surface of activated T cell inhibits T cell proliferation and cytokine production. B7H1 plays a negative regulatory role in peripheral tolerance, autoimmune diseases and chronic infections.B7H1 also has been found to be largely expressed on a broad range of cancers and is thought to contribute to immune evasion by cancers. Blockade of B7H1/PD-1 pathway may contribute to the treatment of autoimmune diseases and maligant tumors.