CAJ | 학술논문

变态反应性疾病是常见病,病因复杂,皮肤癣菌是重要的致病真菌,也是常见的致敏原.近年陆续有个案报道,合并皮肤癣菌感染的变态反应性疾病抗真菌治疗有效.研究者发现,两者之间有密切联系,同时认为暴露于癣菌素抗原,可产生IgE抗体,在易感染个体中可引起过敏症状.概述皮肤癣菌致敏机制、皮肤癣菌抗原、合并皮肤癣菌病的变态反应性疾病治疗等方面以及两者相关性的研究,为部分变态反应性疾病病因学、发病机制及治疗方法提供新思路.
변태반응성질병시상견병,병인복잡,피부선균시중요적치병진균,야시상견적치민원.근년륙속유개안보도,합병피부선균감염적변태반응성질병항진균치료유효.연구자발현,량자지간유밀절련계,동시인위폭로우선균소항원,가산생IgE항체,재역감염개체중가인기과민증상.개술피부선균치민궤제、피부선균항원、합병피부선균병적변태반응성질병치료등방면이급량자상관성적연구,위부분변태반응성질병병인학、발병궤제급치료방법제공신사로.
Allergic diseases are common conditions with complex etiological factors.Dermatophytes are important pathogenic fungi as well as common allergens.As several reports have indicated,oral antifungal therapy is effective for the management of allergic diseases.It has been demonstrated that there is a strong association between dermatophytosis and allergic diseases,and the exposure to dermatophyte antigens may induce the production of IgE antibody and result in allergic symptoms in predisposed individuals.This review mainly presents sensitizing mechanism of dermatophytes,dermatophyte antigens,and treatment of allergic diseases complicated by dermatophytosis with a focus on the association between dermatophytosis and allergic diseases,which may provide new ideas for researches into the etiology,pathogenesis,and treatment of some allergic diseases.