CAJ | 학술논문

近年来,DNA疫苗已在寄生虫病、结核病、艾滋病、肿瘤等领域进行了广泛的研究,但其保护作用常常并不理想.不同物种在密码子使用上的偏性导致外源抗原基冈在不同宿主中不能有效表达,这可能是影响DNA疫苗效能的主要凶素之一.已证实密码子优化后能显著增加蛋白的表达量,提高疫苗的保护率.该文就密码子偏性、密码子优化以及其在疟疾、艾滋病等DNA疫苗中的应用研究进展作一介绍.
근년래,DNA역묘이재기생충병、결핵병、애자병、종류등영역진행료엄범적연구,단기보호작용상상병불이상.불동물충재밀마자사용상적편성도치외원항원기강재불동숙주중불능유효표체,저가능시영향DNA역묘효능적주요흉소지일.이증실밀마자우화후능현저증가단백적표체량,제고역묘적보호솔.해문취밀마자편성、밀마자우화이급기재학질、애자병등DNA역묘중적응용연구진전작일개소.
In recent years,DNA vaccines have been studied in the fields of parasitic disease,tuberculosis.HIV.tumor and other diseases.But Successful protective effects were not always observed.In a wide variety of organisms,synonymous codons ale used with different frequencies,as a result,foreign genes can't be expressed efficiently in difierent hosts.It has been confirmed that codon-optimized genes can increase their protein expression levels and protective effects.The advances of codon bias.codon optimization and its applications in DNA vaccines of malaria,HIV and other diseases were reviewed.