CAJ | 학술논문

目的观察硫普罗宁联合化疗治疗晚期乳腺癌的疗效及安全性.方法 60例晚期乳腺癌患者随机分为治疗组28例和对照组32例,两组化疗方案均为长春瑞滨+顺铂,治疗组加用硫普罗宁,疗程10 d,观察两组临床疗效及不良反应发生情况.结果治疗组有效率为46.4%,对照组为46.9%,差异无统计学意义(P>0.05).治疗组KPS评分下降率17.9%,明显低于对照组的43.8%,两组间差异有统计学意义(P<0.05).治疗组肝功能损害率(9.4%)及白细胞下降率(46.4%)明显低于对照组(31.2%、81.2%)(P<0.05、P<0.01).结论硫普罗宁能降低晚期乳腺癌患者化疗的不良反应,改善了患者的生存质量,且不影响化疗的疗效,值得临床推广应用.
목적 관찰류보라저연합화료치료만기유선암적료효급안전성.방법 60례만기유선암환자수궤분위치료조28례화대조조32례,량조화료방안균위장춘서빈+순박,치료조가용류보라저,료정10 d,관찰량조림상료효급불량반응발생정황.결과 치료조유효솔위46.4%,대조조위46.9%,차이무통계학의의(P>0.05).치료조KPS평분하강솔17.9%,명현저우대조조적43.8%,량조간차이유통계학의의(P<0.05).치료조간공능손해솔(9.4%)급백세포하강솔(46.4%)명현저우대조조(31.2%、81.2%)(P<0.05、P<0.01).결론 류보라저능강저만기유선암환자화료적불량반응,개선료환자적생존질량,차불영향화료적료효,치득림상추엄응용.
Objective To observe the efficacy and safety of tiopronin supplemented with chemotherapy in treating advanced breast cancer.Methods Sixty patients with advanced breast cancer were randomly divided into two groups:treatment group(n = 28) and control group (n = 32).Two groups were treated the same of NVB + DDP,the treatment group was supplemented with tiopronin,given for 10 days.Efficacy,toxicity in two groups were compared.Results The effective rate in the treatment group and the control group were 46.4% and 46.9% respectively, with no significant difference between the two groups ,P > 0.05.But the improved quality of life of patients in the treatment group was higher than that in the control group, P < 0.05.The rate of adverse reaction in liver function damaged (9.4%)and leucocyte lassitude(46.4%) were apparent lower than those in the control group(31.2% ,81.2% ),with significant difference between the two groups(P < 0.05, P < 0.01).Conclusion Tiopronin supplemented with chemotherapy show apparent effect in decreasing the adverse reaction of chemotherapy,improving the quality of life and not influence efficacy in advanced breast cancer.So tiopronln may act as protective drug for chemotherapy and deserve further testing in the clinic.