中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
5期
18-20
,共3页
赖卫强%潘学峰%金冲%张黎明%张春玲%周勇%张慧林
賴衛彊%潘學峰%金遲%張黎明%張春玲%週勇%張慧林
뢰위강%반학봉%금충%장려명%장춘령%주용%장혜림
白细胞介素1β%胃肿瘤%多态现象,遗传%病理特征
白細胞介素1β%胃腫瘤%多態現象,遺傳%病理特徵
백세포개소1β%위종류%다태현상,유전%병리특정
Interleukin-1 beta%Stomach neoplasms%Polymorphism,genetic%Pathological features
目的 研究白细胞介素(IL)-1β 基因多态性与人胃癌发病风险及病理特征的关系.方法 选择2010年1-12月经病理确诊为胃癌标本200例(病例组),慢性浅表性胃炎标本200例(对照组),提取DNA后应用基因芯片技术检测IL-1β 基因-511、-31、-1473、+3954位点的多态性.观察IL-1β 基因-511、-31、-1473、+3954位点的多态性与胃癌发病风险及临床病理参数的关系.结果 病例组IL-1β 基因-511、-31、-1473、+3954位点的T等位基因频率分布分别为48.75％(195/400)、55.25％(221/400)、53.25％(213/400)、50.75％(203/400),与对照组的47.25％(189/400)、53.00％(212/400)、52.50％ (210/400)、52.50％(210/400)比较差异有统计学意义(P＜0.05).IL-1β 基因-511、-31位点的T等位基因胃癌分化程度较低,IL-1β 基因-511、-1473位点的T等位基因胃癌发生年龄相对较早.结论 IL-1β 基因-511、-31、-1473、+3954位点基因型增加胃癌发病的风险.IL-1β 基因-511、-31位点的T等位基因与胃癌的分化程度有关,IL-1β 基因-511、-1473位点的T等位基因与胃癌患者的年龄具有相关性.
目的 研究白細胞介素(IL)-1β 基因多態性與人胃癌髮病風險及病理特徵的關繫.方法 選擇2010年1-12月經病理確診為胃癌標本200例(病例組),慢性淺錶性胃炎標本200例(對照組),提取DNA後應用基因芯片技術檢測IL-1β 基因-511、-31、-1473、+3954位點的多態性.觀察IL-1β 基因-511、-31、-1473、+3954位點的多態性與胃癌髮病風險及臨床病理參數的關繫.結果 病例組IL-1β 基因-511、-31、-1473、+3954位點的T等位基因頻率分佈分彆為48.75％(195/400)、55.25％(221/400)、53.25％(213/400)、50.75％(203/400),與對照組的47.25％(189/400)、53.00％(212/400)、52.50％ (210/400)、52.50％(210/400)比較差異有統計學意義(P＜0.05).IL-1β 基因-511、-31位點的T等位基因胃癌分化程度較低,IL-1β 基因-511、-1473位點的T等位基因胃癌髮生年齡相對較早.結論 IL-1β 基因-511、-31、-1473、+3954位點基因型增加胃癌髮病的風險.IL-1β 基因-511、-31位點的T等位基因與胃癌的分化程度有關,IL-1β 基因-511、-1473位點的T等位基因與胃癌患者的年齡具有相關性.
목적 연구백세포개소(IL)-1β 기인다태성여인위암발병풍험급병리특정적관계.방법 선택2010년1-12월경병리학진위위암표본200례(병례조),만성천표성위염표본200례(대조조),제취DNA후응용기인심편기술검측IL-1β 기인-511、-31、-1473、+3954위점적다태성.관찰IL-1β 기인-511、-31、-1473、+3954위점적다태성여위암발병풍험급림상병리삼수적관계.결과 병례조IL-1β 기인-511、-31、-1473、+3954위점적T등위기인빈솔분포분별위48.75％(195/400)、55.25％(221/400)、53.25％(213/400)、50.75％(203/400),여대조조적47.25％(189/400)、53.00％(212/400)、52.50％ (210/400)、52.50％(210/400)비교차이유통계학의의(P＜0.05).IL-1β 기인-511、-31위점적T등위기인위암분화정도교저,IL-1β 기인-511、-1473위점적T등위기인위암발생년령상대교조.결론 IL-1β 기인-511、-31、-1473、+3954위점기인형증가위암발병적풍험.IL-1β 기인-511、-31위점적T등위기인여위암적분화정도유관,IL-1β 기인-511、-1473위점적T등위기인여위암환자적년령구유상관성.
Objective To investigate the correlation between polymorphism of interleukin(IL)-1β genes and risk and pathological characteristics of gastric cancer in human.Methods From January to December 2010,200 cases of gastric cancer (patient group) and 200 cases of chronic superficial gastritis (control group) were collected.DNA was extracted and IL-1β gene -511,-31,-1473,+3954 site were detected by gene chip technology.The correlation between IL-1β gene -511,-31,-1473,+3954 site and risk and pathological characteristic of gastric cancer was observed.Results The genotype frequency of IL-1β gene -511,-31,-1473,+3954 site was 48.75％(195/400),55.25％(221/400),53.25％(213/400),50.75％ (203/400) in patient group,47.25％ (189/400),53.00％ (212/400),52.50％ (210/400),52.50％ (210/400) in control group,and there was significant difference between two groups (P ＜0.05).While IL-1β gene -511,-31 site T allelic with the lower degree of differentiation of gastric cancer,IL-1 β gene -511,-1473 site T allelic with the early age of gastric cancer.Conclusions IL-1β gene -511,-31,-1473,+3954 site genotype increase the risk of gastric cancer.IL-1β gene -511,-31 site T allelic are related with the degree of differentiation of gastric cancer.IL-1β gene -511,-1473 site T allelic are related with age of gastric cancer patient.
