中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
12期
1930-1932
,共3页
结构脂肪乳%氮平衡%蛋白质代谢%肝脏手术
結構脂肪乳%氮平衡%蛋白質代謝%肝髒手術
결구지방유%담평형%단백질대사%간장수술
Structured triglyceride%Nitrogen balance%Protein metabolism%Liver operation
目的 观察结构脂肪乳对肝脏术后患者肝功能、氮平衡及蛋白质代谢的影响.方法 将肝脏手术患者86例双盲、随机分为结构脂肪乳(STG)组和物理混合的中/长链脂肪乳(MCT/LCT)组.于术后第1～6天接受等氮等热量肠外营养.对比观察术后两组患者肝酶学、氮平衡、血浆蛋白质水平情况.结果在进行6 d的肠外营养以后,两组患者肝酶学指标差异无统计学意义(P>0.05),胆红素在POD+1明显升高,但STG组随后显著下降,MCT/LCT组下降速度慢于STG组(P<0.05).STG组氮平衡明显优于MCT/LCT组.POD+4 STG组蛋白质水平恢复至术前水平,而MCT/LCT组至POD+7才恢复至术前水平.结论 结构脂肪乳由于具有较好的节氮作用,能有效地改善肝脏术后患者的蛋白质代谢,将有利于这类患者术后更快地恢复.
目的 觀察結構脂肪乳對肝髒術後患者肝功能、氮平衡及蛋白質代謝的影響.方法 將肝髒手術患者86例雙盲、隨機分為結構脂肪乳(STG)組和物理混閤的中/長鏈脂肪乳(MCT/LCT)組.于術後第1～6天接受等氮等熱量腸外營養.對比觀察術後兩組患者肝酶學、氮平衡、血漿蛋白質水平情況.結果在進行6 d的腸外營養以後,兩組患者肝酶學指標差異無統計學意義(P>0.05),膽紅素在POD+1明顯升高,但STG組隨後顯著下降,MCT/LCT組下降速度慢于STG組(P<0.05).STG組氮平衡明顯優于MCT/LCT組.POD+4 STG組蛋白質水平恢複至術前水平,而MCT/LCT組至POD+7纔恢複至術前水平.結論 結構脂肪乳由于具有較好的節氮作用,能有效地改善肝髒術後患者的蛋白質代謝,將有利于這類患者術後更快地恢複.
목적 관찰결구지방유대간장술후환자간공능、담평형급단백질대사적영향.방법 장간장수술환자86례쌍맹、수궤분위결구지방유(STG)조화물리혼합적중/장련지방유(MCT/LCT)조.우술후제1～6천접수등담등열량장외영양.대비관찰술후량조환자간매학、담평형、혈장단백질수평정황.결과재진행6 d적장외영양이후,량조환자간매학지표차이무통계학의의(P>0.05),담홍소재POD+1명현승고,단STG조수후현저하강,MCT/LCT조하강속도만우STG조(P<0.05).STG조담평형명현우우MCT/LCT조.POD+4 STG조단백질수평회복지술전수평,이MCT/LCT조지POD+7재회복지술전수평.결론 결구지방유유우구유교호적절담작용,능유효지개선간장술후환자적단백질대사,장유리우저류환자술후경쾌지회복.
Objective To study the influence of structured triglyceride on liver function,nitrogen balance and protein metabolism in surgical patients with liver disease.Methods A prospective,random,and double-blind clinical trial was performed,and 86 surgical patients with liver disease were randomly divided into two groups according to the treatment of structured triglyceride (STG) or physical mixture of medium-chain/long-chain triglycerides (MCT/LCT) emulsion.Both groups received isonitrogenous and isocaloric parenteral nutrition (PN) in the six days after operation.The liver function,nitrogen balance and protein metabolism were compared between the two groups.Results There were no harmful to liver function in both groups.There is less influence on the biliburbin metabolism in STG group as compared with MCT/LCT group.The nitrogen balance in the STG group was significantly higher than those in the MCT/LCT group.The serum level of proteins in STG group back to the normal value on POD +4,while in MCT/LCT group was on POD +7.Conclusion STG can improve the nutrition of surgical patients with liver disease more rapidly than MCT/LCT.
