心理应激过程中免疫功能变化的研究
심리응격과정중면역공능변화적연구
Change of immune function in psychological stress
  • 万方数据
    中国临床康复 중국림상강복
    CHINESE JOURNAL OF CLINICAL REHABILITATION
    2006年 2期 189-192 ,共4页

    韩美君%马殿丽

    한미군%마전려

    应激,心理学%应激/病理生理学%生活变动事件%心理生理性障碍%免疫,细胞%免疫活性 應激,心理學%應激/病理生理學%生活變動事件%心理生理性障礙%免疫,細胞%免疫活性
    응격,심이학%응격/병리생이학%생활변동사건%심리생이성장애%면역,세포%면역활성
    目的:当遇到紧张刺激,可影响生理、心理及免疫功能,产生的免疫反应也可以影响其他生理功能及心理感受,导致生理和/或行为的反应.综述国外对应激刺激时机体分子水平变化的研究现状,探讨免疫功能在心理应激过程中的变化及其意义.资料来源:应用计算机检索Medline1997-01/2003-12的与脑卒中早期康复相关文献,检索词"stress,immune,depression,neuropsychiatric disor-der",并限定文献语种为英文.资料选择:对资料进行初审,从中选取包括应激组和对照组的文献,然后选择是随机临床实验的研究和实验室实验的研究纳入标准.排除标准:非随机临床实验研究,重复的同一研究和综述类文献.资料提炼:共收集到43篇关于应激刺激时机体分子水平变化的随机对照临床实验和实验室的实验研究,25篇纳入标准.排除的18篇中7篇是重复的同一研究,11篇为Meta分析研究.25个实验分别对心理应激刺激时免疫细胞的变化,细胞因子及其受体的变化,免疫功能变化的神经内分泌因素进行了评价.资料综合:应激刺激对生理、心理及免疫功能影响的分子基础包括多种直接的信息网和神经内分泌及免疫细胞和免疫源性介质的反馈调节作用.①免疫细胞的变化:应激反应与神经激肽细胞活性抑制及淋巴细胞对有丝分裂原的增殖反应降低和IL-2、IFN-γ产生抑制有关;老年群体抑郁症与神经激肽-T细胞亚群升高有关;单核细胞的反应性氧作用系统细胞内水平与抑郁性紊乱患者的神经激肽细胞活性降低存在明显的相关性.②细胞因子及其受体的变化:心理性应激反应和精神病学疾病可危及免疫功能的安全,此现象的发生机理可能与免疫系统细胞因子的活性和其他炎症调节因子有关.③免疫功能变化的神经内分泌因素:细胞因子主动转运到中枢神经系统,也从神经胶质细胞中释放,激活中枢神经系统的神经胶质细胞产生其他的细胞因子;心理应激与疾病的关系是经过下列连锁的过程:紧张性刺激,对应激刺激的反应,神经内分泌的改变,免疫应答失调,疾病的发生.结论:心理应激对免疫功能的影响机制是十分复杂的,涉及到中枢神经内分泌系统和免疫系统共同作用.只有寻求更广泛的神经内分泌学和免疫学在心理应激过程中的改变及这些变化与健康和疾病的关系,才能扩大对应激、抑郁与健康、疾病的理解,才能增强防御的能力.
    목적:당우도긴장자격,가영향생리、심리급면역공능,산생적면역반응야가이영향기타생리공능급심리감수,도치생리화/혹행위적반응.종술국외대응격자격시궤체분자수평변화적연구현상,탐토면역공능재심리응격과정중적변화급기의의.자료래원:응용계산궤검색Medline1997-01/2003-12적여뇌졸중조기강복상관문헌,검색사"stress,immune,depression,neuropsychiatric disor-der",병한정문헌어충위영문.자료선택:대자료진행초심,종중선취포괄응격조화대조조적문헌,연후선택시수궤림상실험적연구화실험실실험적연구납입표준.배제표준:비수궤림상실험연구,중복적동일연구화종술류문헌.자료제련:공수집도43편관우응격자격시궤체분자수평변화적수궤대조림상실험화실험실적실험연구,25편납입표준.배제적18편중7편시중복적동일연구,11편위Meta분석연구.25개실험분별대심리응격자격시면역세포적변화,세포인자급기수체적변화,면역공능변화적신경내분비인소진행료평개.자료종합:응격자격대생리、심리급면역공능영향적분자기출포괄다충직접적신식망화신경내분비급면역세포화면역원성개질적반궤조절작용.①면역세포적변화:응격반응여신경격태세포활성억제급림파세포대유사분렬원적증식반응강저화IL-2、IFN-γ산생억제유관;노년군체억욱증여신경격태-T세포아군승고유관;단핵세포적반응성양작용계통세포내수평여억욱성문란환자적신경격태세포활성강저존재명현적상관성.②세포인자급기수체적변화:심이성응격반응화정신병학질병가위급면역공능적안전,차현상적발생궤리가능여면역계통세포인자적활성화기타염증조절인자유관.③면역공능변화적신경내분비인소:세포인자주동전운도중추신경계통,야종신경효질세포중석방,격활중추신경계통적신경효질세포산생기타적세포인자;심리응격여질병적관계시경과하렬련쇄적과정:긴장성자격,대응격자격적반응,신경내분비적개변,면역응답실조,질병적발생.결론:심리응격대면역공능적영향궤제시십분복잡적,섭급도중추신경내분비계통화면역계통공동작용.지유심구경엄범적신경내분비학화면역학재심리응격과정중적개변급저사변화여건강화질병적관계,재능확대대응격、억욱여건강、질병적리해,재능증강방어적능력.
    OBJECTIVE: Tension affects the functions in physiology, psychology and immunity. The immune reaction induced may affect other physiological functions and psychological feelings, resulting in reaction in physiology and/or behavior. The present state in the studies on organic molecular changes during stress at home and broad was synthesized so as to explore the change of immune function in psychological stress and its significance.DATA SOURCE: Relevant literatures on early rehabilitation of cerebral apoplexy were looked up in Medline from January 1997 to December 2003.The retrieved words: "stress, immune, depression, neuropsychiatric disorder", limited in English.STUDY SELECTION: By first examination of data, the literatures with stress group and the control involved were selected, and then researches on randomized clinical experimental study and laboratory experiment were included. Excluded criteria: the researches without randomized clinical experiment, repeated research and synthetic literature were excluded.DATA EXTRACTION: Totally, 43 papers on randomized-controlled clinical experimental research and laboratory experiment on organic molecular changes in stress were collected and 25 papers of them were employed. Of 18 excluded papers, 7 papers referred to therepeated research and 11 papers are Meta analyzing study. Totally 25 experiments have evaluated the change of immunocytes, change of cytokines and their receptors and neuroendocrinal factors in change of immune function during psychological stress.DATA SYNTHESIS:DATA SYNTHESIS: The molecule mechanism of stress on physiological,psychological and immunological functions is based on feedback regulation of multiple direct information net, neuroendocrinal cell, immunoctye and immunological medium. ① Change of immunocyte: Stress is associated with inhibition of neurokinin cell activity, reduced proliferation and inhibition of lymphocyte to mitogen and to IL-2 and IFN-γ respectively. Senile depression is related with the increased subgroup of neurokinin-T cell. Levels of monocyte reactive oxygen species are remarkably correlative with decreased natural killer cell activity in patient with depressive disorder. ② Change of cytokines and their receptors: Psychological stress and neuropsychiatric disorder threaten the safety of immune function, the mechanism of which is probably related to the activity of cytokines in immune system and other regulating factors of inflammation. ③ Neuroendocrinal factors in change of immune function: Cytokine transports actively to central nerve system and is also released from neurogial cell to activate neurogial cell in central nerve system to produce other cytokines. The chain between stress and disease is as follows: tension-stress response-alternation of neuroendocrine-imbalance of immune response-incidence of disease.CONCLUSION: The mechanism of the effects of psychological stress on immune function is very complicated, involving the coordination of central neuroendocrinal system and immune system. Only the relationship between the alternations of neuroendocrinology and immunology in psychology with health and disease is searched more extensively, does the understanding be enhanced on the interconnection of stress, depression, health and disease and the defensive capacity intensified.
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