中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2012年
4期
229-233
,共5页
刘恩彬%陈辉树%张培红%李占琦%孙琦%杨晴英%方立环%孙福军
劉恩彬%陳輝樹%張培紅%李佔琦%孫琦%楊晴英%方立環%孫福軍
류은빈%진휘수%장배홍%리점기%손기%양청영%방립배%손복군
白血病,大颗粒淋巴细胞%病理学,临床%骨髓检查
白血病,大顆粒淋巴細胞%病理學,臨床%骨髓檢查
백혈병,대과립림파세포%병이학,림상%골수검사
Leukemia,large granular lymphocytic%Pathology,clinical%Bone marrow examination
目的 探讨T大颗粒淋巴细胞白血病(T-LGLL)的血液病理学特点.方法 回顾性分析2005年11月至2010年4月收集的19例T-LGLL患者的临床资料、骨髓形态、免疫表型及分子遗传学情况.结果 19例患者中最常见的血液学异常为贫血(16例)与中性粒细胞减少(17例).17例外周血涂片可见大颗粒淋巴细胞.骨髓涂片示17例淋巴细胞比例增高(>0.2),15例可见大颗粒淋巴细胞.骨髓活检切片示16例淋巴细胞增多,其中12例为轻至中度增多.骨髓切片中淋巴细胞均为间质型分布,8例可见血窦内分布,4例可见淋巴细胞结节.流式细胞学示13例CD3+ CD4 -CD8+ CD56 CD57+.6例免疫标记不典型,为CD8 1例、CD56+2例、CD57-3例.免疫组织化学示CD3(10/10)、CD57(3/3)、CD8( 6/7)、T细胞胞内抗原-1(TIA-1,6/7)、颗粒酶B(4/7)、穿孔素(1/7)阳性,CD4(4/4)、CD56 (9/9)阴性.T细胞受体(TCR)γ基因重排检测12例阳性(12/17).结论大多数T-LGLL具有典型的血液病理学特点.外周血与骨髓的形态学、免疫表型及分子遗传学检测是T-LGLL诊断与鉴别诊断中必不可少的内容,三者互为补充.
目的 探討T大顆粒淋巴細胞白血病(T-LGLL)的血液病理學特點.方法 迴顧性分析2005年11月至2010年4月收集的19例T-LGLL患者的臨床資料、骨髓形態、免疫錶型及分子遺傳學情況.結果 19例患者中最常見的血液學異常為貧血(16例)與中性粒細胞減少(17例).17例外週血塗片可見大顆粒淋巴細胞.骨髓塗片示17例淋巴細胞比例增高(>0.2),15例可見大顆粒淋巴細胞.骨髓活檢切片示16例淋巴細胞增多,其中12例為輕至中度增多.骨髓切片中淋巴細胞均為間質型分佈,8例可見血竇內分佈,4例可見淋巴細胞結節.流式細胞學示13例CD3+ CD4 -CD8+ CD56 CD57+.6例免疫標記不典型,為CD8 1例、CD56+2例、CD57-3例.免疫組織化學示CD3(10/10)、CD57(3/3)、CD8( 6/7)、T細胞胞內抗原-1(TIA-1,6/7)、顆粒酶B(4/7)、穿孔素(1/7)暘性,CD4(4/4)、CD56 (9/9)陰性.T細胞受體(TCR)γ基因重排檢測12例暘性(12/17).結論大多數T-LGLL具有典型的血液病理學特點.外週血與骨髓的形態學、免疫錶型及分子遺傳學檢測是T-LGLL診斷與鑒彆診斷中必不可少的內容,三者互為補充.
목적 탐토T대과립림파세포백혈병(T-LGLL)적혈액병이학특점.방법 회고성분석2005년11월지2010년4월수집적19례T-LGLL환자적림상자료、골수형태、면역표형급분자유전학정황.결과 19례환자중최상견적혈액학이상위빈혈(16례)여중성립세포감소(17례).17예외주혈도편가견대과립림파세포.골수도편시17례림파세포비례증고(>0.2),15례가견대과립림파세포.골수활검절편시16례림파세포증다,기중12례위경지중도증다.골수절편중림파세포균위간질형분포,8례가견혈두내분포,4례가견림파세포결절.류식세포학시13례CD3+ CD4 -CD8+ CD56 CD57+.6례면역표기불전형,위CD8 1례、CD56+2례、CD57-3례.면역조직화학시CD3(10/10)、CD57(3/3)、CD8( 6/7)、T세포포내항원-1(TIA-1,6/7)、과립매B(4/7)、천공소(1/7)양성,CD4(4/4)、CD56 (9/9)음성.T세포수체(TCR)γ기인중배검측12례양성(12/17).결론대다수T-LGLL구유전형적혈액병이학특점.외주혈여골수적형태학、면역표형급분자유전학검측시T-LGLL진단여감별진단중필불가소적내용,삼자호위보충.
Objective To explore the hematopathologic features of T-cell large granular lymphocytic leukemia (T-LGLL). Methods A retrospective analysis of the clinical presentation,bone marrow morphology,immunophenotyping and T-cell receptor gene rearrangement status wcrc performed in 19 patients with T-LGLL. Results Of 19 patients,the most frequent hematological abnormalities were anemia and neutropenia (16/19 and 17/19 patients,respectively).Large granular lymphocytes (LGLs) were observed in 17 of 19 peripheral blood smears and 15 of 19 bone marrow aspirate specimens.Lymphocytosis ( >0.2)was present in 17 of 19 patients in their bone marrow aspirate specimens.Bone marrow biopsy specimens revealed lymphocytosis in 16 cases,with a mild to moderate increase of lymphocytes observed in 12 cases (12/16). The pattern of lymphoid distribution was interstitial in bone marrow sections. Intravascular distribution was seen in 8 cases. Lymphoid nodules were present in 4 cases. Flow cytometery showed an immunophenotype of CD3 + CD4 - CD8 + CD56 - CD57 + of the tumor cells in 13 cases.Of the other 6 cases,the immunophenotypes included CD8- ( 1 case), CD56+ (2 cases) and CD57 ( 3 cases).Immunohistochemistry showed CD3 + ( 10/10 ),CD57 + ( 3/3 ),CD8 + ( 6/7 ),TIA-1 + ( 6/7 ),granzyme B + (4/7),perforin + ( 1/7),CD4 - (4/4) and CD56 - (9/9).Clonal T-cell rcccptor γ gene rearrangement by PCR was detected in 12 cases (12/17).Conclusions Hematopathologic features of most T-LGLL are distinct.Morphologic,immunophenotypic and molecular analysis of both peripheral blood and bone marrow specimens are essential and complementary in the diagnosis and differential diagnosis of T-LGLL.