CAJ | 학술논문

癌转移是指恶性肿瘤细胞脱离原发病灶,然后通过各种转移方式,到达另一(些)组织和器官后得以继续繁殖生长,形成性质和原发肿瘤相同或相近的续发肿瘤的全过程.阐明癌症转移的分子机制有益于发现抑制其浸润转移的新途径.小泛素相关修饰物(SUMO)是一种类泛素化蛋白,可以修饰大量的转录因子和共转录因子.近年来报道了一些SUM()化修饰的与肿瘤浸润和转移相关的蛋白质,现对这些发现及其在癌症转移中的重要生物学作用作一综述.
암전이시지악성종류세포탈리원발병조,연후통과각충전이방식,도체령일(사)조직화기관후득이계속번식생장,형성성질화원발종류상동혹상근적속발종류적전과정.천명암증전이적분자궤제유익우발현억제기침윤전이적신도경.소범소상관수식물(SUMO)시일충류범소화단백,가이수식대량적전록인자화공전록인자.근년래보도료일사SUM()화수식적여종류침윤화전이상관적단백질,현대저사발현급기재암증전이중적중요생물학작용작일종술.
Cancer metastasis is a process by which tumor cells spread almost uncontrollably from primary tumor to form secondary tumors at a distant organ in the body. Elucidating the mechanism by which this complex process is controlled at the molecular level will be tremendously helpful in developing new therapeutic approaches for treating metastatic cancer. Small ubiquitin-related modifier(SUMO),a member of ubiquitin-like proteins,modifies a large number of transcription factors and coregulators. It has been reported that a number of cancer metastasis associated proteins undergo SUMOylation, including reptin, HIF-1α, Ets family, NF-κB. This article overviews these findings and discusses biological importance of protein SUMOylation in cancer infiltration and metastasis.