中华航空航天医学杂志
中華航空航天醫學雜誌
중화항공항천의학잡지
CHINESE JOURNAL OF AEROSPACE MEDICINE
2011年
3期
224-229
,共6页
鲁炳怀%朱凤霞%吕红%王广进
魯炳懷%硃鳳霞%呂紅%王廣進
로병부%주봉하%려홍%왕엄진
血红蛋白A,糖基化%血糖%糖尿病,2型%数据收集
血紅蛋白A,糖基化%血糖%糖尿病,2型%數據收集
혈홍단백A,당기화%혈당%당뇨병,2형%수거수집
Hemoglobin A,glycosylated%Blood glucose%Diabetes mellitus,type 2%Date collection
目的 探讨民航飞行员糖化血红蛋白Alc(glycated hemoglobin Alc,HbAlc)水平及其在筛查空腹血糖受损(impaired fasting glucose,IFG)及2型糖尿病(type 2 diabetes mellitus,T2DM)中的应用.方法 151例参加例行体检的民航飞行员纳入本次研究,同时选取96例普通体检人群作为对照组,分别测定其空腹血糖(fasting plasma glucose,FPG)、脂代谢指标、肝肾功能指标与HbAlc,所得结果用于统计分析.根据飞行员的不同HbAlc及FPG水平,分析两者之间的相关性.结果 民航飞行员HbAlc水平与普通人群相比无显著差异；民航飞行员IFG组与T2DM组的HbAlc较正常组均显著增高(P＜0.01)；多因素回归分析显示FPG、γ-谷氨酰转肽酶、谷丙转氨酶、血清肌酐水平是HbAlc的独立影响因素；受试者工作特征曲线显示HbAlc在5.6％与6.2％时分别是IFG与T2DM诊断与筛查的最佳临界值.结论 民航飞行员中,HbAlc可作为IFG及T2DM筛查、心血管疾病危险性评估的重要指标.对于服用降糖药物的民航飞行员,飞行体检时除了将FPG作为常规监测项目外,应考虑将HbAlc作为糖代谢状况的评估指标.
目的 探討民航飛行員糖化血紅蛋白Alc(glycated hemoglobin Alc,HbAlc)水平及其在篩查空腹血糖受損(impaired fasting glucose,IFG)及2型糖尿病(type 2 diabetes mellitus,T2DM)中的應用.方法 151例參加例行體檢的民航飛行員納入本次研究,同時選取96例普通體檢人群作為對照組,分彆測定其空腹血糖(fasting plasma glucose,FPG)、脂代謝指標、肝腎功能指標與HbAlc,所得結果用于統計分析.根據飛行員的不同HbAlc及FPG水平,分析兩者之間的相關性.結果 民航飛行員HbAlc水平與普通人群相比無顯著差異；民航飛行員IFG組與T2DM組的HbAlc較正常組均顯著增高(P＜0.01)；多因素迴歸分析顯示FPG、γ-穀氨酰轉肽酶、穀丙轉氨酶、血清肌酐水平是HbAlc的獨立影響因素；受試者工作特徵麯線顯示HbAlc在5.6％與6.2％時分彆是IFG與T2DM診斷與篩查的最佳臨界值.結論 民航飛行員中,HbAlc可作為IFG及T2DM篩查、心血管疾病危險性評估的重要指標.對于服用降糖藥物的民航飛行員,飛行體檢時除瞭將FPG作為常規鑑測項目外,應攷慮將HbAlc作為糖代謝狀況的評估指標.
목적 탐토민항비행원당화혈홍단백Alc(glycated hemoglobin Alc,HbAlc)수평급기재사사공복혈당수손(impaired fasting glucose,IFG)급2형당뇨병(type 2 diabetes mellitus,T2DM)중적응용.방법 151례삼가례행체검적민항비행원납입본차연구,동시선취96례보통체검인군작위대조조,분별측정기공복혈당(fasting plasma glucose,FPG)、지대사지표、간신공능지표여HbAlc,소득결과용우통계분석.근거비행원적불동HbAlc급FPG수평,분석량자지간적상관성.결과 민항비행원HbAlc수평여보통인군상비무현저차이；민항비행원IFG조여T2DM조적HbAlc교정상조균현저증고(P＜0.01)；다인소회귀분석현시FPG、γ-곡안선전태매、곡병전안매、혈청기항수평시HbAlc적독립영향인소；수시자공작특정곡선현시HbAlc재5.6％여6.2％시분별시IFG여T2DM진단여사사적최가림계치.결론 민항비행원중,HbAlc가작위IFG급T2DM사사、심혈관질병위험성평고적중요지표.대우복용강당약물적민항비행원,비행체검시제료장FPG작위상규감측항목외,응고필장HbAlc작위당대사상황적평고지표.
Objective To investigate the glycated hemoglobin Alc level (HbAlc) and its role in diagnosing impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) in civil pilots.Methods One hundred and fifty-one civil pilots,who were in routine physical examination in Civil Aviation General Hospital,were chosen as pilot group and 96 common examined personnel were taken as control group.The pilot goup was further analyzed by different HbAlc and FPG level to get the correlation between them.The level of fasting plasma glucose (FPG),lipid profiles,liver and renal function markers and HbAlc were measured and analyzed.Results No difference of HbAlc was observed between pilot and control group.The HbAlc levcl was significantly higher in IFG and T2DM sub-group than that in normal glucose sub-group (P＜0.01).The multiple linear regression analysis indicated that FPG,γ-glutamyl transferase (γ-GT),alanine transaminase (ALT),and serum creatinine (SCr) were the significant and independent influencing factors against HbAlc.The receiver operating characteristic (ROC) curve showed that HbAlc at the level of 5.6％ and 6.2％ was the best cut-off value for diagnosing and screening IFG and T2DM.Conclusions HbAlc may be the key indicator in diagnosing and monitoring IFG and T2DM,as well as in evaluating cardiovascular disease incidence for civil pilot.Besides routinely monitoring FPG in physical examination,HbAlc should be the indicator in assessing glucose metabolism for the pilot with T2DM and taking hypoglycemic drugs.
