CAJ | 학술논문

目的观察不同剂量黄芪注射液对血浆脑钠肽(BNP)水平的影响,间接评价其对心力衰竭(心衰)的治疗作用.方法将入选的90例患者随机分为三组(对照组、20 ml黄芪组、40 ml黄芪组).入院后三组均常规抗心衰治疗,不同剂量黄芪注射液组在常规治疗基础上加用不同剂量黄芪注射液,治疗2周,酶联免疫吸附实验法测定血浆BNP水平.结果 20ml黄芪组总有效率为90.0％,40 ml黄芪组总有效率为96.7％,对照组总有效率为86.7％.不同剂量黄芪组总有效率优于对照组(P＜0.05)；不同剂量黄芪组间对比,差异有统计学意义(P＜0.05).治疗后三组血浆BNP水平均较治疗前有明显下降(P＜0.05)；心率、血压、左室射血分数、心排血量及心脏指数比较,差异有统计学意义(P＜0.05).结论在常规抗心力衰竭药物的基础上加用黄芪能降低血浆BNP水平,明显改善心功能,黄芪对心力衰竭有一定的治疗作用.
목적 관찰불동제량황기주사액대혈장뇌납태(BNP)수평적영향,간접평개기대심력쇠갈(심쇠)적치료작용.방법 장입선적90례환자수궤분위삼조(대조조、20 ml황기조、40 ml황기조).입원후삼조균상규항심쇠치료,불동제량황기주사액조재상규치료기출상가용불동제량황기주사액,치료2주,매련면역흡부실험법측정혈장BNP수평.결과 20ml황기조총유효솔위90.0％,40 ml황기조총유효솔위96.7％,대조조총유효솔위86.7％.불동제량황기조총유효솔우우대조조(P＜0.05)；불동제량황기조간대비,차이유통계학의의(P＜0.05).치료후삼조혈장BNP수평균교치료전유명현하강(P＜0.05)；심솔、혈압、좌실사혈분수、심배혈량급심장지수비교,차이유통계학의의(P＜0.05).결론 재상규항심력쇠갈약물적기출상가용황기능강저혈장BNP수평,명현개선심공능,황기대심력쇠갈유일정적치료작용.
Objective To observe the effect of the different doses of astragalus injection on plasma BNP levels,indirectly evaluate the rest of the treatment of heart failure.Methods Ninety patients were randomly selected into three groups (control group,20 ml astragalus group,40 ml astragalus group).After admission,three group were receiving conventional therapy.Astragalus group was in the conventional treatment based on the use of different doses of astragalus injection,the treatment for two weeks,enzyme - linked immunosorbent assay method for the determination of plasma BNP levels.Results The total effective rate in 20 ml astragalus group was 90％,in 40 ml astragalus group was 96.7％,in control group was 86.7％.Different doses of astragalus total effective rate was better than the control group ( P ＜ 0.05 ),and there was significant difference between groups with different doses of astragalus ( P ＜ 0.05).The plasma BNP levels of the three groups after treatment than before treatment was decreased significantly ( P ＜ 0.05 ) ; To compare heart rate,blood pressure,left ventricular ejection fraction (LVEF),cardiac output (CO) and cardiac index (CI) of the three groups has significant difference ( P ＜0.05 ).Conclusions Plus astragalus injection to the conventional anti -heart failure drugs can lower plasma BNP levels,significantly improved cardiac function,astragalus rest of heart failure have a therapeutic effect.