CAJ | 학술논문

目的探讨乳腺癌组织中c-erbB-2和组织蛋白酶D(cath-D)的表达水平与临床病理及预后的关系.方法选取128例乳腺癌患者,采用免疫组化法检测c-erbB-2和cath-D蛋白的表达水平,并与患者的临床病理指标和预后做关联分析.结果 c-erbB-2阳性率为36.5%,cath-D阳性表达率为40.9%.cath-D的表达水平与患者肿块直径大小显著相关,肿瘤直径＞5 cm者cath-D的阳性率显著高于＜2 cm者(x2=21.0,P＜0.0001);cath-D阴性的68例中,24例(35.29%)有淋巴结转移,cath-D阳性者淋巴结转移率(63.83%)明显高于cath-D阴性者(P＜0.0001).c-erbB-2表达比不表达患者预后差(P=0.01).结论 c-erbB-2阳性表达和cath-D阳性表达者,恶性程度高,易转移、预后差.
목적 탐토유선암조직중c-erbB-2화조직단백매D(cath-D)적표체수평여림상병리급예후적관계.방법 선취128례유선암환자,채용면역조화법검측c-erbB-2화cath-D단백적표체수평,병여환자적림상병리지표화예후주관련분석.결과 c-erbB-2양성솔위36.5%,cath-D양성표체솔위40.9%.cath-D적표체수평여환자종괴직경대소현저상관,종류직경＞5 cm자cath-D적양성솔현저고우＜2 cm자(x2=21.0,P＜0.0001);cath-D음성적68례중,24례(35.29%)유림파결전이,cath-D양성자림파결전이솔(63.83%)명현고우cath-D음성자(P＜0.0001).c-erbB-2표체비불표체환자예후차(P=0.01).결론 c-erbB-2양성표체화cath-D양성표체자,악성정도고,역전이、예후차.
Objective To investigate the expression of c-erbB-2 and cathepsin D (cath-D) in primary breast carcinoma, and to analyze its relationship to the patients' clinicopathological status and its prognostic significance. Methods The immnohistochemical test were used to detect the expression of c-erbB-2 and cath-D in 128 patients with primary breast carcinoma. All data were statistically analyzed.Results The positive expression rate of c-erbB-2 and cath-D was 36.5 % and 40.9 %, relatively. Cath-D was correlated with tumor size (x2 =21.0, P ＜0.0001) and lymph node status (35.29 % vs 63.83 %, P ＜0.0001). The Kaplan-Meier curve and log rank test indicated that the positive c-erbB-2 expression was a significant prognostic factor for patients disease free survival (P＜0.01). Conclusion c-erbB-2 and cath-D show a clinicopathological invasive characteristic. They are prognostic factors for patients with primary breast carcinoma, and also can be prognostic indicator for patients.