肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2011年
2期
100-102
,共3页
徐岗%邵中夫%邓晓芳%何利珍
徐崗%邵中伕%鄧曉芳%何利珍
서강%소중부%산효방%하리진
乳腺肿瘤%DNA拓扑异构酶Ⅱα%环氧化酶2
乳腺腫瘤%DNA拓撲異構酶Ⅱα%環氧化酶2
유선종류%DNA탁복이구매Ⅱα%배양화매2
Breast neoplasms%DNA Topoisomerase Ⅱα%Cyclooxygenase 2
目的 探讨拓扑异构酶Ⅱα(TopoⅡα)和环氧合酶-2(COX-2)在乳腺癌组织中的表达及其与临床病理特征的关系.方法 采用免疫组织化学法检测50例乳腺癌组织中TopoⅡα和COX-2的表达.结果 TopoⅡα在乳腺癌及其周围正常乳腺组织中表达率分别为64%(32/50)和22%(11/50);COX-2在乳腺癌及其周围正常乳腺组织中表达率分别为68%(34/50)和14%(7/50),差异均有统计学意义(P＜0.05).TopⅡα的表达仅与乳腺癌组织学分级有关(P＜0.05),而与患者年龄、肿瘤大小、淋巴结转移和临床分期无关(P＞0.05);COX-2表达与肿瘤大小、组织学分级、淋巴结转移和临床分期有关(P＜0.05),而与患者年龄无关(P＞0.05).结论 TopoⅡα和COX-2的检测可作为评价乳腺癌分化程度和侵袭、转移的指标.
目的 探討拓撲異構酶Ⅱα(TopoⅡα)和環氧閤酶-2(COX-2)在乳腺癌組織中的錶達及其與臨床病理特徵的關繫.方法 採用免疫組織化學法檢測50例乳腺癌組織中TopoⅡα和COX-2的錶達.結果 TopoⅡα在乳腺癌及其週圍正常乳腺組織中錶達率分彆為64%(32/50)和22%(11/50);COX-2在乳腺癌及其週圍正常乳腺組織中錶達率分彆為68%(34/50)和14%(7/50),差異均有統計學意義(P＜0.05).TopⅡα的錶達僅與乳腺癌組織學分級有關(P＜0.05),而與患者年齡、腫瘤大小、淋巴結轉移和臨床分期無關(P＞0.05);COX-2錶達與腫瘤大小、組織學分級、淋巴結轉移和臨床分期有關(P＜0.05),而與患者年齡無關(P＞0.05).結論 TopoⅡα和COX-2的檢測可作為評價乳腺癌分化程度和侵襲、轉移的指標.
목적 탐토탁복이구매Ⅱα(TopoⅡα)화배양합매-2(COX-2)재유선암조직중적표체급기여림상병리특정적관계.방법 채용면역조직화학법검측50례유선암조직중TopoⅡα화COX-2적표체.결과 TopoⅡα재유선암급기주위정상유선조직중표체솔분별위64%(32/50)화22%(11/50);COX-2재유선암급기주위정상유선조직중표체솔분별위68%(34/50)화14%(7/50),차이균유통계학의의(P＜0.05).TopⅡα적표체부여유선암조직학분급유관(P＜0.05),이여환자년령、종류대소、림파결전이화림상분기무관(P＞0.05);COX-2표체여종류대소、조직학분급、림파결전이화림상분기유관(P＜0.05),이여환자년령무관(P＞0.05).결론 TopoⅡα화COX-2적검측가작위평개유선암분화정도화침습、전이적지표.
Objective To explore the expression of Topo Ⅱα and COX-2 in breast cancer tissues and investigate their correlations to clinicopathologic feature of breast cancer. Methods The expression of Topo Ⅱα and COX-2 in 50 specimens of breast cancer and their normal tissues were detected by immunohistochemistry. Their correlation to clinicopathologic features of breast cancer were analyzed.Results The positive rates of Topo Ⅱα were 64 % (32/50) and 22 % (11/50) and COX-2 were 68 % (34/50) , 14 %(7/50) in breast cancer and normal tissue (P＜0.05). The expression of Topo Ⅱα was correlated to degree of differentiation (P ＜0.05), not correlated to patient age, tumor size, clinical stage and lymph node metastasis(P ＞0.05). The expression of COX-2 was correlated to tumor size, degree of differentiation, clinical stage and lymph node metastasis (P ＜0.05), not correlated to patient age (P ＞0.05). Conclusion Topo Ⅱα and COX-2 expression can be used as an indicator for predicting the differentiation, infiltration and metastasis characteristics of breast cancer.
