天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2008年
5期
839-841
,共3页
金叶子%膜结合型PGE2合酶-1%类风湿性关节炎%槲皮素%番石榴苷%栎素
金葉子%膜結閤型PGE2閤酶-1%類風濕性關節炎%槲皮素%番石榴苷%櫟素
금협자%막결합형PGE2합매-1%류풍습성관절염%곡피소%번석류감%력소
Craibiodendron yunnanense%mPGES-1%rheumatoid arthritis%Quercetin%Guaijaverin%Quercitrin
在从天然产物筛选抗炎物质的过程中,应用有机溶媒萃取、浓缩及层析分离纯化后,从金叶子中得到三个化合物:槲皮素(1)、番石榴苷(2)、栎素(3).化合物2为首次从此植物中分离鉴定,化合物1显示了强烈的抑制mPGES-1基因表达的活性,其IC50值为35.40μg/mL.
在從天然產物篩選抗炎物質的過程中,應用有機溶媒萃取、濃縮及層析分離純化後,從金葉子中得到三箇化閤物:槲皮素(1)、番石榴苷(2)、櫟素(3).化閤物2為首次從此植物中分離鑒定,化閤物1顯示瞭彊烈的抑製mPGES-1基因錶達的活性,其IC50值為35.40μg/mL.
재종천연산물사선항염물질적과정중,응용유궤용매췌취、농축급층석분리순화후,종금협자중득도삼개화합물:곡피소(1)、번석류감(2)、력소(3).화합물2위수차종차식물중분리감정,화합물1현시료강렬적억제mPGES-1기인표체적활성,기IC50치위35.40μg/mL.
In the course of searching for anti-inflammatory agents from natural products,three known compounds were i-selated from the ethanol extract of the leaves of Craibiodendron yunnanense W. W. Smith and identified as quercetin (1) ,quercetin 3-O-α-L-arabinopyranoside (guaijaverin,2), quercetin 3-O-α-L-rhamnopyrancside (quercitrin,3). Com-pound 2 was isolated for the first time from this plant. Among these compounds,compound 1 showed significant bioactivi-ty against mPGES-1 expression with IC50 value of 35.40μg/mL.
