CAJ | 학술논문

目的探讨新生儿ABO溶血病(ABO-HDN)溶血三项试验不同结果与胆红素水平的相关性.方法对85例ABO-HDN患儿进行血清溶血三项试验[抗人球蛋白试验(DAT)、游离抗体试验、抗体释放试验]、母亲IgG抗A(B)抗体、血清胆红素等测定.结果 ABO-HDN患儿DAT阳性者血清总胆红素峰值与DAT阴性者比较,差异有统计学意义(P＜0.05,0.01);DAT阴性间比较、DAT阳性间比较(P＞0.05),差异无统计学意义.新生儿ABO-HDN患儿母亲血型抗体与血清总胆红素水平比较,差异无统计学意义(P＞0.05).结论 ABO-HDN患儿DAT阳性合并抗体释放试验阳性或三项试验均阳性时,血清胆红素水平增高较明显,DAT阴性释放试验和/或游离试验阳性时,新生儿ABO-HDN相对较轻,而母亲IgG抗体效价高低不能反映HDN的严重程度,这可为临床合理治疗HDN提供帮助.
목적 탐토신생인ABO용혈병(ABO-HDN)용혈삼항시험불동결과여담홍소수평적상관성.방법 대85례ABO-HDN환인진행혈청용혈삼항시험[항인구단백시험(DAT)、유리항체시험、항체석방시험]、모친IgG항A(B)항체、혈청담홍소등측정.결과 ABO-HDN환인DAT양성자혈청총담홍소봉치여DAT음성자비교,차이유통계학의의(P＜0.05,0.01);DAT음성간비교、DAT양성간비교(P＞0.05),차이무통계학의의.신생인ABO-HDN환인모친혈형항체여혈청총담홍소수평비교,차이무통계학의의(P＞0.05).결론 ABO-HDN환인DAT양성합병항체석방시험양성혹삼항시험균양성시,혈청담홍소수평증고교명현,DAT음성석방시험화/혹유리시험양성시,신생인ABO-HDN상대교경,이모친IgG항체효개고저불능반영HDN적엄중정도,저가위림상합리치료HDN제공방조.
Objective To study the relevance between different results of three hemolysis detection tests and serum bilirubin levels of ABO hemolytic disease of the newborn(ABO-HDN).Methods Serological hemolysis three tests (direct anti-human globulin test,free antibody test,antibody release test),maternal anti-A (B)IgG antibodies,serum bilirubin were examined in 85 cases of ABO-HDN.Results There were significant differences in levels of total serum bilirubin (TSB) between groups of DAT-positive and groups of DAT-negative (P ＜ 0.05,or P ＜ 0.01).There weren' t significants difference between groups of DAT-positive or groups of DAT-negative in levels of total serum bilirubin(P ＞ 0.05).There wasn' t significant difference between maternal antibodies titer and levels of total serum bilirubin (P ＞ 0.05).Conclusion When DAT is positive,the serum bilirubin level was significantly increased,and maternal antibodies titer couldn' t show severity of ABO-HDN.It could be helpfull for the clinical treatment of ABO-HDN.