CAJ | 학술논문

目的观察羟苯磺酸钙联合厄贝沙坦治疗早期糖尿病肾病(DN)的临床疗效.方法早期DN患者65例,随机分为治疗组(34例)和对照组(31例),两组均采用厄贝沙坦治疗,治疗组加用羟苯磺酸钙治疗,疗程均为24周.观察并比较治疗前后两组的空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)和24h尿蛋白排泄率(UAER)的变化.结果疗程结束后,两组UAER均有明显降低(t=8.074,12.89,均P＜0.01),而且治疗组UAER低于同期对照组水平(t=3.965,P＜0.01).结论羟苯磺酸钙和厄贝沙坦联合应用能减少早期DN患者尿蛋白排泄率,延缓糖尿病肾病进展.
목적 관찰간분광산개연합액패사탄치료조기당뇨병신병(DN)적림상료효.방법 조기DN환자65례,수궤분위치료조(34례)화대조조(31례),량조균채용액패사탄치료,치료조가용간분광산개치료,료정균위24주.관찰병비교치료전후량조적공복혈당(FBG)、찬후2h혈당(PBG)、당화혈홍단백(HbA1c)화24h뇨단백배설솔(UAER)적변화.결과 료정결속후,량조UAER균유명현강저(t=8.074,12.89,균P＜0.01),이차치료조UAER저우동기대조조수평(t=3.965,P＜0.01).결론 간분광산개화액패사탄연합응용능감소조기DN환자뇨단백배설솔,연완당뇨병신병진전.
Objective To observe the therapeutic effects of calcium dobesilate combined with irbesartan in treating early diabetic nephropathy ( DN ).Methods 65 patients with early DN were randomly divided into two groups,experiment group( irbesartan plus calcium dobesilate,n =34) and control group( irbesartan,n =31 ).After 24 week treatment,the urinary albumin excretion rate(UAER),fasting blood glucose ( FBG ),postprandial blood glucose (PBG) and glycosylated hemoglobin(HbA1c) were detected and compared between two groups before and after treat ment.Results UAER after treatment was significantly reduced in both 2 groups(t =8.074,12.89,all P＜0.01),and the decrement in the experiment group was more obvious than that in the control group with statistical significance ( t =3.965,P ＜ 0.05).Conclusion Calcium dobesilate combined with irbesartan has good effects in the treatment of early DN.