中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
11期
1481-1483,1488
,共4页
心脏瓣膜假体植入%手术期间%心肌/代谢%肌钙蛋白L/代谢%脂肪酸结合蛋白质类/代谢
心髒瓣膜假體植入%手術期間%心肌/代謝%肌鈣蛋白L/代謝%脂肪痠結閤蛋白質類/代謝
심장판막가체식입%수술기간%심기/대사%기개단백L/대사%지방산결합단백질류/대사
Heart valve prosthesis implantation%Intraoperative period%Myocardium/ME%Troponin L/ME%Fatty acid-binding proteins/ME
目的 探讨心脏瓣膜置换术后心肌肌钙蛋白I(cTnI)和心型脂肪酸结合蛋白(H-FABP)的变化规律.方法 选本院风湿性心脏病手术患者40例,随机分为晶体停搏液灌注组和冷血停搏液灌注组,选取8个时间点,分析和比较各时点血清cTnI和H-FABP浓度变化规律.结果 晶体停搏液灌注组cTnI组间及交互效应差异均有统计学意义(F组间=2744.397,P＜0.01; F交互=125.345,P＜0.01),冷血停搏液灌注组cTnI组间及交互效应差异均有统计学意义(F组间=1056.357,P＜0.01; F交互 =64.242,P＜0.01)；晶体停搏液灌注组H- FABP组间及交互效应差异均有统计学意义(F组间=1775.022,P＜0.01;F交互=34.297,P＜0.01),冷血停搏液灌注组H -FABP组间及交互效应差异均有统计学意义(F组间=3064.451,P＜0.01;F交互=60.472,P＜0.01).结论 H-FABP心肌的特异性强,有效诊断窗口期短,较符合心肌损伤的理想判定标志物.
目的 探討心髒瓣膜置換術後心肌肌鈣蛋白I(cTnI)和心型脂肪痠結閤蛋白(H-FABP)的變化規律.方法 選本院風濕性心髒病手術患者40例,隨機分為晶體停搏液灌註組和冷血停搏液灌註組,選取8箇時間點,分析和比較各時點血清cTnI和H-FABP濃度變化規律.結果 晶體停搏液灌註組cTnI組間及交互效應差異均有統計學意義(F組間=2744.397,P＜0.01; F交互=125.345,P＜0.01),冷血停搏液灌註組cTnI組間及交互效應差異均有統計學意義(F組間=1056.357,P＜0.01; F交互 =64.242,P＜0.01)；晶體停搏液灌註組H- FABP組間及交互效應差異均有統計學意義(F組間=1775.022,P＜0.01;F交互=34.297,P＜0.01),冷血停搏液灌註組H -FABP組間及交互效應差異均有統計學意義(F組間=3064.451,P＜0.01;F交互=60.472,P＜0.01).結論 H-FABP心肌的特異性彊,有效診斷窗口期短,較符閤心肌損傷的理想判定標誌物.
목적 탐토심장판막치환술후심기기개단백I(cTnI)화심형지방산결합단백(H-FABP)적변화규률.방법 선본원풍습성심장병수술환자40례,수궤분위정체정박액관주조화랭혈정박액관주조,선취8개시간점,분석화비교각시점혈청cTnI화H-FABP농도변화규률.결과 정체정박액관주조cTnI조간급교호효응차이균유통계학의의(F조간=2744.397,P＜0.01; F교호=125.345,P＜0.01),랭혈정박액관주조cTnI조간급교호효응차이균유통계학의의(F조간=1056.357,P＜0.01; F교호 =64.242,P＜0.01)；정체정박액관주조H- FABP조간급교호효응차이균유통계학의의(F조간=1775.022,P＜0.01;F교호=34.297,P＜0.01),랭혈정박액관주조H -FABP조간급교호효응차이균유통계학의의(F조간=3064.451,P＜0.01;F교호=60.472,P＜0.01).결론 H-FABP심기적특이성강,유효진단창구기단,교부합심기손상적이상판정표지물.
Objective To explore change trend of Cardiac Troponin Ⅰ (cTnI) and Heart Fatty Acid-binding Protein(H-FABP) in serum during the perioperation of valve replacement.Methods Forty patients with heumatoid valvular heart disease were selected for this study,and the patients were randomly divided into two groups.Blood samples were taken from center vein,and the serum levels of cTnI and H-FABP were determined.The change of the serum levels of these two markers at different time points was recorded and compared between two groups.Results There were significant differences in the concentration of cTnl in the cold crystalloid cardioplegia group ( F between group =2744.397,P ＜0.01 ; F interaction =125.345,P ＜0.01 ).There were significant differences in the concentration of cTnI in the cold blood cardioplegia group ( F between group =1056.357,P ＜ 0.01 ; Finteraction =64.242,P ＜ 0.01 ).There were significant differences in the concentration of H - FABP in the cold crystalloid cardioplegia group ( F between group =1775.022,P ＜0.01; F interaction =34.297,P ＜0.01 ).There were significant differences in the concentration of H -FABP in the cold blood cardioplegia group ( F between group =3064.451,P ＜0.01; Finteraction =60.472,P ＜O.01 ).Conclusions H-FABP is suitable for early diagnosis of myocardial injury because of its myocardial specificity.There are positive correlation between the peak of H-FABP and myocardial injury.There are effective and short period of window for prediction of myocardial injury caused by H-FABP.H-FABP may be served as a good myocardial injury diagnostic markers.
