中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2010年
10期
774-779
,共6页
寿张轩%何俏军%褚永权%赵仲生
壽張軒%何俏軍%褚永權%趙仲生
수장헌%하초군%저영권%조중생
胃肿瘤%基质金属蛋白酶%胰岛素样生长因子%预后
胃腫瘤%基質金屬蛋白酶%胰島素樣生長因子%預後
위종류%기질금속단백매%이도소양생장인자%예후
Stomach neoplasms%Matrix metalloproteinase%Insulin-like growth factor%Prognosis
目的 探讨基质金属蛋白酶-2(MMP-2)和胰岛素样生长因子-1(IGF-1)两种蛋白在胃癌组织中的表达及其临床病理意义.方法 应用免疫组化方法检测436例胃癌组织和92例非肿瘤胃黏膜组织中MMP-2和IGF-1蛋白的表达情况,分析MMP-2和IGF-1与胃癌浸润、转移和预后之间的关系.结果 胃癌组织中MMP-2和IGF-1的高表达率分别为70.4%(307/436)和49.5%(216/436),明显高于非肿瘤胃黏膜组织中的3.3%(3/92,P<0.05)和5.4%(5/92,P<0.05),两种蛋白在胃癌组织中的表达水平均与肿瘤患者的年龄、肿瘤大小、肿瘤部位、Lauren分型、TNM分期、浸润深度、脉管侵犯、远处转移和淋巴结转移存在相关性(P值均<0.05);MMP-2和IGF-1两种蛋白的表达呈正相关(P<0.05);按TNM分期的单因素生存分析表明,MMP-2高表达与Ⅰ～Ⅱ期胃癌患者的预后不良相关(P值均<0.05),IGF-1高表达与Ⅰ～Ⅲ期胃癌患者的预后不良有关(P值均<0.05);MMP-2和IGF-1的高表达均为胃癌的独立预后因素.结论 MMP-2和IGF-1参与了胃癌的侵袭、转移过程,同时检测MMP-2和IGF-1两种蛋白的表达有助于判断胃癌患者预后.
目的 探討基質金屬蛋白酶-2(MMP-2)和胰島素樣生長因子-1(IGF-1)兩種蛋白在胃癌組織中的錶達及其臨床病理意義.方法 應用免疫組化方法檢測436例胃癌組織和92例非腫瘤胃黏膜組織中MMP-2和IGF-1蛋白的錶達情況,分析MMP-2和IGF-1與胃癌浸潤、轉移和預後之間的關繫.結果 胃癌組織中MMP-2和IGF-1的高錶達率分彆為70.4%(307/436)和49.5%(216/436),明顯高于非腫瘤胃黏膜組織中的3.3%(3/92,P<0.05)和5.4%(5/92,P<0.05),兩種蛋白在胃癌組織中的錶達水平均與腫瘤患者的年齡、腫瘤大小、腫瘤部位、Lauren分型、TNM分期、浸潤深度、脈管侵犯、遠處轉移和淋巴結轉移存在相關性(P值均<0.05);MMP-2和IGF-1兩種蛋白的錶達呈正相關(P<0.05);按TNM分期的單因素生存分析錶明,MMP-2高錶達與Ⅰ～Ⅱ期胃癌患者的預後不良相關(P值均<0.05),IGF-1高錶達與Ⅰ～Ⅲ期胃癌患者的預後不良有關(P值均<0.05);MMP-2和IGF-1的高錶達均為胃癌的獨立預後因素.結論 MMP-2和IGF-1參與瞭胃癌的侵襲、轉移過程,同時檢測MMP-2和IGF-1兩種蛋白的錶達有助于判斷胃癌患者預後.
목적 탐토기질금속단백매-2(MMP-2)화이도소양생장인자-1(IGF-1)량충단백재위암조직중적표체급기림상병리의의.방법 응용면역조화방법검측436례위암조직화92례비종류위점막조직중MMP-2화IGF-1단백적표체정황,분석MMP-2화IGF-1여위암침윤、전이화예후지간적관계.결과 위암조직중MMP-2화IGF-1적고표체솔분별위70.4%(307/436)화49.5%(216/436),명현고우비종류위점막조직중적3.3%(3/92,P<0.05)화5.4%(5/92,P<0.05),량충단백재위암조직중적표체수평균여종류환자적년령、종류대소、종류부위、Lauren분형、TNM분기、침윤심도、맥관침범、원처전이화림파결전이존재상관성(P치균<0.05);MMP-2화IGF-1량충단백적표체정정상관(P<0.05);안TNM분기적단인소생존분석표명,MMP-2고표체여Ⅰ～Ⅱ기위암환자적예후불량상관(P치균<0.05),IGF-1고표체여Ⅰ～Ⅲ기위암환자적예후불량유관(P치균<0.05);MMP-2화IGF-1적고표체균위위암적독립예후인소.결론 MMP-2화IGF-1삼여료위암적침습、전이과정,동시검측MMP-2화IGF-1량충단백적표체유조우판단위암환자예후.
Objective To investigate the expression of matrix metalloproteinase-2 (MMP-2) and insulin-like growth factor-1 (IGF-1) in gastric carcinoma and their clinicopathological significance. Methods Expressions of MMP-2 and IGF-1 were examined by using immunohistochemical SP staining and cross- compared with clinicopathological features of gastric carcinoma. Results High expression of MMP-2 and IGF-1 were observed in 70.4% (307/436) and 49. 5% (216/436) of gastric carcinoma tissues respectively, significantly higher than those in non-tumor gastric mocosa(3. 3% and 5.4% , respectively; all P <0.05). The high expression rate of MMP-2 and IGF-1 were significantly associated with the patient age, tumor size, tumor location, Lauren classification, TNM staging, depth of tumor infiltration, presence of vessel invasion, lymph node and distant metastasis ( all P < 0. 05 ). In addition, the expression of MMP-2 was positively linked with the expression level of IGF-1 (P<0.05). Univariate analysis showed that high expression of MMP-2, was significantly associated with poor prognosis of tumor of TNM stage I and II ( all P < 0. 05 ) , high expression of IGF-1 was significantly correlated with poor prognosis of patients with TNM stage Ⅰ , Ⅱ and Ⅲtumor (all P < 0. 05). Cox multivariate analysis indicated that the high expressions of MMP-2 and IGF-1 could be independent prognostic indices for gastric carcinoma. Conclusions High expression of MMP-2 and IGF-1 proteins are significantly correlated with the invasion and metastasis of gastric carcinoma,it is helpful to simultaneously detect the expressions of MMP-2 and IGF-1 proteins in predicting prognosis of patients with gastric carcinoma.
