CAJ | 학술논문

目的从冠状血管造影和超声心动图的角度探讨不同特征代谢综合征(MS)组分的聚集与冠状动脉病变程度和左心室肥厚(LVH)的关系.方法 2000年至2004年间入院并进行冠状动脉造影的患者492例,根据MS定义中代谢异常组分的累加评分(0～4分)分为5组.比较各组间冠心病(CHD)发生比例、严重程度及左心室质量等差异.结果随着代谢异常的增加,左前降支血管狭窄百分数,狭窄血管数目,冠脉狭窄积分及CHD比例均随之增加(P值分别为0.002,0.008,0.007,0.042);室间隔厚度、左心室后壁厚度和左心室质量也随之增加(P值分别为0.016,0.02,0.03).Logistic回归分析结果显示,代谢异常评分每增加1分,发生CHD的相对危险度增加1.29倍(95%CI:1.09～1.53).结论 MS患者更易发生冠状动脉狭窄和LVH,且随着代谢异常的累积,冠脉狭窄程度、受累血管数目和左心室质量也有所增加.
목적 종관상혈관조영화초성심동도적각도탐토불동특정대사종합정(MS)조분적취집여관상동맥병변정도화좌심실비후(LVH)적관계.방법 2000년지2004년간입원병진행관상동맥조영적환자492례,근거MS정의중대사이상조분적루가평분(0～4분)분위5조.비교각조간관심병(CHD)발생비례、엄중정도급좌심실질량등차이.결과 수착대사이상적증가,좌전강지혈관협착백분수,협착혈관수목,관맥협착적분급CHD비례균수지증가(P치분별위0.002,0.008,0.007,0.042);실간격후도、좌심실후벽후도화좌심실질량야수지증가(P치분별위0.016,0.02,0.03).Logistic회귀분석결과현시,대사이상평분매증가1분,발생CHD적상대위험도증가1.29배(95%CI:1.09～1.53).결론 MS환자경역발생관상동맥협착화LVH,차수착대사이상적루적,관맥협착정도、수루혈관수목화좌심실질량야유소증가.
Objective To examine the effect of aggregations of MS components on angiographic coronary artery disease severity and echocardiographic left ventricular hypertrophy.Methods We evaluated 492 hospitalized patients aged 29~88 years in Huashan Hospital in 2000-2004 who underwent elective coronary angiography.Patients were categorized into 0 to 5 groups according to component number of metabolic syndrome.The severity of lesion,sum of lesion vessels,rate of coronary artery disease and left ventricular mass(left ventricular mass index)were compared among groups.Results As the metabolic disorder score increased,so did the parameters of stenosis percentages of three main coronary arteries,the number of lesion vessels,and coronary stenosis score(P value was 0.002,0.268,0.136,0.008,0.007,respectively).As the score increased,so did the interventricular septal thickness,posterior wall thickness,left ventricular mass and left ventricular mass index(P value was 0.016,0.02,0.03,and 0.021,respectively).When metabolic disoirder score increased by 1 point,the relative risk of the coronary artery disease prevalence elevated by 1.29(95%CI:1.09-1.53).Conclusions The degree of metabolic disorder clustering is strongly related to the severity of coronary artery disease and left ventricular hypertrophy.