CAJ | 학술논문

目的探讨女性下生殖道细菌性阴道病(BV)、念珠菌性阴道炎(VVC)单纯感染与混合感染之间治疗后复发率和易复发率的差别,以寻求有效的治疗和预防措施.方法以阴道分泌物半定量法、湿片法和培养法对临床药物治疗状态进行综合分析.结果7 595例外阴阴道炎病例中单纯BV、单纯VVC和BV-VVC混合感染的患病率为56.6%(4 295/7 595)、30.68%(2 330/7 595)和12.77%(970/7595);复发率分别为4.07%(175/7 595)、7.89%(184/7 595)和48.56%(471/7 595),前二者与后者间差异有显著性P＜0.01.830例复发病例中,BV、VVC单纯感染和混合感染的易复发率分别为1.7%(3/175),4.89%(9/84)和10.19%(48/471),前二者与后者间差异有显著性P＜0.05.结论BV、VVC混合感染导致VVC复发率、易复发率明显增高;VVC合并BV是VVC复发的一个重要因素,应引起临床高度关注及有效的系统治疗.
목적탐토녀성하생식도세균성음도병(BV)、념주균성음도염(VVC)단순감염여혼합감염지간치료후복발솔화역복발솔적차별,이심구유효적치료화예방조시.방법이음도분비물반정량법、습편법화배양법대림상약물치료상태진행종합분석.결과7 595예외음음도염병례중단순BV、단순VVC화BV-VVC혼합감염적환병솔위56.6%(4 295/7 595)、30.68%(2 330/7 595)화12.77%(970/7595);복발솔분별위4.07%(175/7 595)、7.89%(184/7 595)화48.56%(471/7 595),전이자여후자간차이유현저성P＜0.01.830례복발병례중,BV、VVC단순감염화혼합감염적역복발솔분별위1.7%(3/175),4.89%(9/84)화10.19%(48/471),전이자여후자간차이유현저성P＜0.05.결론BV、VVC혼합감염도치VVC복발솔、역복발솔명현증고;VVC합병BV시VVC복발적일개중요인소,응인기림상고도관주급유효적계통치료.
[Objective] To evaluate the benefit of BV treatment with regard to VVC reoccurrence among women who live in the Northeast region of China. [Methods] 7595 women presenting vaginitis-related symptoms were enrolled between age 18 and 74, with a median of 36, in Shenyang. Microscopic examination of wet mount was carried out for all vaginal specimens. BV was diagnosed by the BVBLUE(R) test (Gryphus Diagnostics, USA), a sialidase-based rapid diagnostic kit for BV. VVC was diagnosed initially on the wet mount by microscopic examination, and in follow-up cases of recurrent VVC by the Vitek 2 system (bioMerieux, France) after vaginal culture. Treatment of BV was provided by metronidazole, and VVC by imidazoles. [Results] Treatment of BV cases by metronidazole and VVC cases by imidazole was generally effective. The recurrent rate was very low in the single infection cases (175/4295, 4.07%, for BV; and 184/2330, 7.89%, for VVC). Significant differences were observed in the recurrent rate of BV and VVC when compared with the recurrent rate of concurrent BV and VVC infection. A total of 970 cases were diagnosed for having both VVC and BV. The recurrent rate was 48.56% (471/970) among these patients despite of treatment of BV and VVC with metronidazole and imidazole, respectively. The rate of high recurrent incidences (≥4episodes per year) was also higher (10.19%, 48/471) in patients with BV and VVC compared to those who had only BV (2.94%, 5/175) or VVC (4.89%, 9/184). [Conclusions] The study indicated that the recurrent rate of BV and VVC is dramatically increased if patients have both BV and VVC in comparison with those who have only BV or VVC. It is therefore beneficial to correctly diagnose BV and VVC in each case, and prescribe treatment for both diseases concurrently.