CAJ | 학술논문

蛋白质二硫键异构酶(protein disulfide isomerage,PDI)家族是一类在内质网中起作用的巯基-二硫键氧化还原酶.它们通常含有CXXC(Cys-Xaa-Xaa-Cys,CXXC)活性位点,活性位点的两个半胱氨酸残基可催化底物二硫键的形成、异构及还原.所有PDI家族成员包含至少一个约100个氨基酸残基的硫氧还蛋白同源结构域.PDI家族的主要职能是催化内质网中新生肽链的氧化折叠,另外在内质网相关的蛋白质降解途径(ERAD)、蛋白质转运、钙稳态、抗原提呈及病毒入侵等方面也起重要作用.
단백질이류건이구매(protein disulfide isomerage,PDI)가족시일류재내질망중기작용적구기-이류건양화환원매.타문통상함유CXXC(Cys-Xaa-Xaa-Cys,CXXC)활성위점,활성위점적량개반광안산잔기가최화저물이류건적형성、이구급환원.소유PDI가족성원포함지소일개약100개안기산잔기적류양환단백동원결구역.PDI가족적주요직능시최화내질망중신생태련적양화절첩,령외재내질망상관적단백질강해도경(ERAD)、단백질전운、개은태、항원제정급병독입침등방면야기중요작용.
The protein disulfide isomerase(PDI)family proteins are a group of dithiol-disulfide oxidoreductase located at the endoplasmic reticulum(ER).They usually contain at least one Cys-Xaa-Xaa-Cys(CXXC)active site that can catalyze disulfide formation,reduction,and isomerization.The PDI family proteins primarily function as catalysts of the oxidative protein folding in the ER lumen,but they are also involved in other processes,such as ER-associated degradation(ERAD),trafficking,calcium homeostasis,antigen presentation and virus entry.Regardless of their functions,PDI family proteins all contain at least one thioredoxin-like domain.