CAJ | 학술논문

目的应用蛋氨酸(MET)PET-GT鉴别脑胶质瘤放疗后复发与坏死.方法 30例放疗后怀疑复发或坏死的胶质瘤患者接受MET PET-CT检查,放疗结束与PET-CT检查间隔时间中位数13.5个月.复发诊断根据病理结果,坏死诊断根据病理结果或临床随访.结果 19例MET PET-CT 检查后考虑复发患者接受手术切除或立体定向活检术,其中18例病理确诊为胶质瘤复发,1例病理确诊为坏死.11例PET-CT诊断为放疗后坏死,经长期随访(>6个月)后临床症状稳定及MRI或CT 影像诊断病灶无增大.PET-CT鉴别脑胶质瘤放疗后复发与坏死的敏感性、特异性和准确率分别为100%、91.7%和96.7%.结论 MET PET-CT可有效鉴别脑胶质瘤放疗后复发与坏死.
목적 응용단안산(MET)PET-GT감별뇌효질류방료후복발여배사.방법 30례방료후부의복발혹배사적효질류환자접수MET PET-CT검사,방료결속여PET-CT검사간격시간중위수13.5개월.복발진단근거병리결과,배사진단근거병리결과 혹림상수방.결과 19례MET PET-CT 검사후고필복발환자접수수술절제혹입체정향활검술,기중18례병리학진위효질류복발,1례병리학진위배사.11례PET-CT진단위방료후배사,경장기수방(>6개월)후림상증상은정급MRI혹CT 영상진단병조무증대.PET-CT감별뇌효질류방료후복발여배사적민감성、특이성화준학솔분별위100%、91.7%화96.7%.결론 MET PET-CT가유효감별뇌효질류방료후복발여배사.
Objective To evaluate the role of 11C-methionine positron emission tomographv(MET PET-CT)in differentiating tumor recurrence from radiation necrosis in brain slioma patients.Methods From June 2008 to September 2009,30 brain glioma patients with suspected tumor recurvence or radiation necrosis after radiotherapy were evaluated by MET PET-CT.The median time between initial radiotherapy and PET examination was 13.5 months.Tumor recurrence were confirmed by histological analysis while necrosis was based on histological analysis or the subsequent clinical follow-up.Results Eighteen out of 19 patients were histologically confirmed tumor recurrence among those tumor recurrence shown by MET PET-CT after surgery or stereotactic biopsy.11 patients were considered to have radiation necrosis because of stable neurological sympotoms and without massive enlargement of the lesion during the after follow-up.The sensitivity,specificity and accuracy of MET PET-CT for detecting tumor recurrence were 100%,91.7%and 96.7%respectively.Conclusion MET PET-CT is a powerful tool in differentiating brain tumor recurrence from radiation necrosis after radiotherapy.