中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
4期
458-460
,共3页
王荣珍%陆颜燕%田永华%蒙开熠
王榮珍%陸顏燕%田永華%矇開熠
왕영진%륙안연%전영화%몽개습
卵巢肿瘤/代谢%胰岛素样生长因子Ⅱ/代谢%胰岛素样生长因子结合蛋白质3/代谢%手术期间
卵巢腫瘤/代謝%胰島素樣生長因子Ⅱ/代謝%胰島素樣生長因子結閤蛋白質3/代謝%手術期間
란소종류/대사%이도소양생장인자Ⅱ/대사%이도소양생장인자결합단백질3/대사%수술기간
Ovarian neoplasms/ME%Insulin-like growth factor II/ME%Insulin-like growth factor binding protein 3/ME%Intraoperative period
目的 探讨卵巢癌患者围手术期血清胰岛素样生长因子-2(IGF-2)和胰岛素样生长因子结合蛋白-3(IGFBP-3)的变化及其临床意义.方法 采用酶联吸附免疫法(ELISA)测定40例健康对照组及82例卵巢癌患者手术前后血清IGF-2和IGFBP-3的水平,观察健康对照组与卵巢癌患者手术前后血清IGF-2和IGFBP-3的水平变化,分析卵巢癌病人血清IGF-2和IGFBP-3水平与临床特征的关系.结果 卵巢癌手术前病人血清IGF-2及IGFBP-3水平明高于正常对照组[(101.5±22.2)ng/ml,(49.3±15.6)ng/ml vs (69.6±17.7)ng/ml,(23.9±11.3)ng/ml,t＝3.74,2.85,P＜0.05];卵巢癌病人有淋巴结转移者血清IGF-2水平[(109.4±20.0)ng/ml]高于无淋巴结转移者[(89.9±16.6)ng/ml](t′＝4.10,P＜0.05),而IGFBP-3水平[(39.8±11.1)ng/ml]低于无淋巴结转移者[(55.8±19.2)ng/ml](t′＝4.49,P＜0.05);肿瘤临床TNM分期中III～IV期者血清IGF-2水平[(107.5±24.0)ng/ml]高于I～II期者[(91.6±17.7)ng/ml](t＝2.83,P＜0.05),而IGFBP-3水平[(41.7±16.9)ng/ml]低于I～II期者[(56.9±19.1)ng/ml](t＝2.37,P＜0.05),根治性手术组病人术后IGF-2及IGFBP-3水平明显低于术前[(103.4±27.2)ng/ml,(50.2±16.6)ng/ml vs (86.6±12.3)ng/ml,(41.1±17.1)ng/ml,t＝2.48,3.32,P＜0.05],姑息性手术组病人术前术后血清IGF-2及IGFBP-3水平无明显变化(P＞0.05).根治性手术组病人术后血清IGF-2及IGFBP-3水平低于姑息性手术组术后[(86.6±12.3)ng/ml,(41.1±17.1)ng/ml vs (103.2±26.0)ng/ml,(45.3±14.9)ng/ml,t′＝3.46,t＝2.67,P＜0.05].结论 卵巢癌患者血清IGF-2和IGFBP-3的水平与肿瘤的浸润转移、临床分期及根治性手术有关,动态检测卵巢癌患者血清IGF-2和IGFBP-3的变化,有助于估计患者的预后.
目的 探討卵巢癌患者圍手術期血清胰島素樣生長因子-2(IGF-2)和胰島素樣生長因子結閤蛋白-3(IGFBP-3)的變化及其臨床意義.方法 採用酶聯吸附免疫法(ELISA)測定40例健康對照組及82例卵巢癌患者手術前後血清IGF-2和IGFBP-3的水平,觀察健康對照組與卵巢癌患者手術前後血清IGF-2和IGFBP-3的水平變化,分析卵巢癌病人血清IGF-2和IGFBP-3水平與臨床特徵的關繫.結果 卵巢癌手術前病人血清IGF-2及IGFBP-3水平明高于正常對照組[(101.5±22.2)ng/ml,(49.3±15.6)ng/ml vs (69.6±17.7)ng/ml,(23.9±11.3)ng/ml,t＝3.74,2.85,P＜0.05];卵巢癌病人有淋巴結轉移者血清IGF-2水平[(109.4±20.0)ng/ml]高于無淋巴結轉移者[(89.9±16.6)ng/ml](t′＝4.10,P＜0.05),而IGFBP-3水平[(39.8±11.1)ng/ml]低于無淋巴結轉移者[(55.8±19.2)ng/ml](t′＝4.49,P＜0.05);腫瘤臨床TNM分期中III～IV期者血清IGF-2水平[(107.5±24.0)ng/ml]高于I～II期者[(91.6±17.7)ng/ml](t＝2.83,P＜0.05),而IGFBP-3水平[(41.7±16.9)ng/ml]低于I～II期者[(56.9±19.1)ng/ml](t＝2.37,P＜0.05),根治性手術組病人術後IGF-2及IGFBP-3水平明顯低于術前[(103.4±27.2)ng/ml,(50.2±16.6)ng/ml vs (86.6±12.3)ng/ml,(41.1±17.1)ng/ml,t＝2.48,3.32,P＜0.05],姑息性手術組病人術前術後血清IGF-2及IGFBP-3水平無明顯變化(P＞0.05).根治性手術組病人術後血清IGF-2及IGFBP-3水平低于姑息性手術組術後[(86.6±12.3)ng/ml,(41.1±17.1)ng/ml vs (103.2±26.0)ng/ml,(45.3±14.9)ng/ml,t′＝3.46,t＝2.67,P＜0.05].結論 卵巢癌患者血清IGF-2和IGFBP-3的水平與腫瘤的浸潤轉移、臨床分期及根治性手術有關,動態檢測卵巢癌患者血清IGF-2和IGFBP-3的變化,有助于估計患者的預後.
목적 탐토란소암환자위수술기혈청이도소양생장인자-2(IGF-2)화이도소양생장인자결합단백-3(IGFBP-3)적변화급기림상의의.방법 채용매련흡부면역법(ELISA)측정40례건강대조조급82례란소암환자수술전후혈청IGF-2화IGFBP-3적수평,관찰건강대조조여란소암환자수술전후혈청IGF-2화IGFBP-3적수평변화,분석란소암병인혈청IGF-2화IGFBP-3수평여림상특정적관계.결과 란소암수술전병인혈청IGF-2급IGFBP-3수평명고우정상대조조[(101.5±22.2)ng/ml,(49.3±15.6)ng/ml vs (69.6±17.7)ng/ml,(23.9±11.3)ng/ml,t＝3.74,2.85,P＜0.05];란소암병인유림파결전이자혈청IGF-2수평[(109.4±20.0)ng/ml]고우무림파결전이자[(89.9±16.6)ng/ml](t′＝4.10,P＜0.05),이IGFBP-3수평[(39.8±11.1)ng/ml]저우무림파결전이자[(55.8±19.2)ng/ml](t′＝4.49,P＜0.05);종류림상TNM분기중III～IV기자혈청IGF-2수평[(107.5±24.0)ng/ml]고우I～II기자[(91.6±17.7)ng/ml](t＝2.83,P＜0.05),이IGFBP-3수평[(41.7±16.9)ng/ml]저우I～II기자[(56.9±19.1)ng/ml](t＝2.37,P＜0.05),근치성수술조병인술후IGF-2급IGFBP-3수평명현저우술전[(103.4±27.2)ng/ml,(50.2±16.6)ng/ml vs (86.6±12.3)ng/ml,(41.1±17.1)ng/ml,t＝2.48,3.32,P＜0.05],고식성수술조병인술전술후혈청IGF-2급IGFBP-3수평무명현변화(P＞0.05).근치성수술조병인술후혈청IGF-2급IGFBP-3수평저우고식성수술조술후[(86.6±12.3)ng/ml,(41.1±17.1)ng/ml vs (103.2±26.0)ng/ml,(45.3±14.9)ng/ml,t′＝3.46,t＝2.67,P＜0.05].결론 란소암환자혈청IGF-2화IGFBP-3적수평여종류적침윤전이、림상분기급근치성수술유관,동태검측란소암환자혈청IGF-2화IGFBP-3적변화,유조우고계환자적예후.
Objective To investigate the changes of serum insulin-like growth factor-2 (IGF-2) and insulin-link growth factor binding protein-3(IGFBP-3) in the patients with ovarian cancer before and after operation,and evaluate their clinical significance.Methods The contents of serum IGF-2 and IGFBP-3 in 82 patients with ovarian cancer were detected by ELISA before and after operation and compared with that in health controls.Results The contents of IGF-2 in the patients before operation were significantly higher than that in control group[(101.5±22.2)ng/ml,(49.3±15.6)ng/ml vs (69.6±17.7)ng/ml,(23.9±11.3)ng/ml,t＝3.74,2.85,P＜0.05].The contents of IGFBP-3[(39.8±11.1)ng/ml]in the patients before operation were significantly lower than that in control group[(55.8±19.2)ng/ml](t′＝4.49,P＜0.05).There was significant correlation between the contents with lymph node metastasis and clinical stage[(107.5±24.0)ng/ml,(41.7±16.9)ng/ml vs (91.6±17.7)ng/ml,(56.9±19.1)ng/ml;(103.4±27.2)ng/ml,(50.2±16.6)ng/ml vs (86.6±12.3)ng/ml,(41.1±17.1)ng/ml,t＝2.83,2.37,2.48,3.32,P＜0.05).The contents of IGF-2 was significantly decreased,and IGFBP-3 was significantly increased in patients after radical operation [(86.6±12.3)ng/ml,(41.1±17.1)ng/ml vs (103.2±26.0)ng/ml,(45.3±14.9)ng/ml,t′＝3.46,t＝2.67,P＜0.05].But there was no significant difference on the level of IGF-2 and IGFBP-3 before and after palliative resection(P＞0.05).Conclusions The contents of serum IGF-2 and IGFBP-3 are closely related to tumor invasion,metastasis and clinical stage.Dynamic determination of the contents of serum IGF-2 and IGFBP-3 may be an important index for evaluation of invasion,metastasis,efficacy and prognosis for the patients with ovarian cancer.
