中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
26期
32-34
,共3页
魏本尊%沈超%孙广涛%亓荣华
魏本尊%瀋超%孫廣濤%亓榮華
위본존%침초%손엄도%기영화
肝肿瘤%栓塞,治疗性%癌胚抗原%甲胎蛋白类
肝腫瘤%栓塞,治療性%癌胚抗原%甲胎蛋白類
간종류%전새,치료성%암배항원%갑태단백류
Liver neoplasms%Embolization,therapeutic%Carcinoembryonic antigen%Alphafetoproteins
目的 探讨原发性肝癌行肝动脉化疗栓塞术(TACE)围手术期血清甲胎蛋白(AFP)、癌胚抗原(CEA)水平变化.方法 102例原发性肝癌患者,均行TACE治疗,术后3d、1周、3周观察患者血清AFP、CEA水平的变化.结果 血清AFP水平术后3d及术后1周高于术前[(549±30)、(530±30)μg/L比(527±40)μg/L],但差异无统计学意义(P＞0.05),术后3周AFP水平明显降低[(351±20) μg/L],与术前比较差异有统计学意义(P＜0.05)；血清CEA水平术后3d、术后1周及术后3周均低于术前(410±15)、(350±20)、(200±10) μg/L比(570±22)μg/L],差异有统计学意义(P＜0.05),术后3周患者血清AFP、CEA水平均为正常水平.结论 对原发性肝癌患者行TACE,可以明显改善患者的症状,降低患者血清AFP、CEA水平,给予患者有效的治疗,掌握TACE的适应证及禁忌证,进而及时正确地给予患者施行TACE,可以降低患者病死率,改善长期预后,值得临床推广应用.
目的 探討原髮性肝癌行肝動脈化療栓塞術(TACE)圍手術期血清甲胎蛋白(AFP)、癌胚抗原(CEA)水平變化.方法 102例原髮性肝癌患者,均行TACE治療,術後3d、1週、3週觀察患者血清AFP、CEA水平的變化.結果 血清AFP水平術後3d及術後1週高于術前[(549±30)、(530±30)μg/L比(527±40)μg/L],但差異無統計學意義(P＞0.05),術後3週AFP水平明顯降低[(351±20) μg/L],與術前比較差異有統計學意義(P＜0.05)；血清CEA水平術後3d、術後1週及術後3週均低于術前(410±15)、(350±20)、(200±10) μg/L比(570±22)μg/L],差異有統計學意義(P＜0.05),術後3週患者血清AFP、CEA水平均為正常水平.結論 對原髮性肝癌患者行TACE,可以明顯改善患者的癥狀,降低患者血清AFP、CEA水平,給予患者有效的治療,掌握TACE的適應證及禁忌證,進而及時正確地給予患者施行TACE,可以降低患者病死率,改善長期預後,值得臨床推廣應用.
목적 탐토원발성간암행간동맥화료전새술(TACE)위수술기혈청갑태단백(AFP)、암배항원(CEA)수평변화.방법 102례원발성간암환자,균행TACE치료,술후3d、1주、3주관찰환자혈청AFP、CEA수평적변화.결과 혈청AFP수평술후3d급술후1주고우술전[(549±30)、(530±30)μg/L비(527±40)μg/L],단차이무통계학의의(P＞0.05),술후3주AFP수평명현강저[(351±20) μg/L],여술전비교차이유통계학의의(P＜0.05)；혈청CEA수평술후3d、술후1주급술후3주균저우술전(410±15)、(350±20)、(200±10) μg/L비(570±22)μg/L],차이유통계학의의(P＜0.05),술후3주환자혈청AFP、CEA수평균위정상수평.결론 대원발성간암환자행TACE,가이명현개선환자적증상,강저환자혈청AFP、CEA수평,급여환자유효적치료,장악TACE적괄응증급금기증,진이급시정학지급여환자시행TACE,가이강저환자병사솔,개선장기예후,치득림상추엄응용.
Objective To explore the change of perioperative serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in patients with primary liver cancer undertaken transcatbeter arterial chemoembolization (TACE).Methods One hundred and two patients with primary liver cancer were performed with TACE treatment.The levels of AFP and CEA after treatment 3 d,1 week,3 weeks were detected and compared.Results The levels of AFP after treatment 3 d and 1 week were higher than that before treatment,but there was no significant difference [(549 ±30),(530 ±30) μg/L vs. (527 ±40) μg/L] (P ＞ 0.05).After treatment 3 weeks,the levels of AFP significantly decreased than that before treatment [ (351 ± 20) μ g/L vs.(527 ± 40) μ g/L ] (P ＜ 0.05 ).The levels of CEA after treatment 3 d,1 week,3 weeks were significantly lower than that before treatment [(410 ± 15),(350 ± 20),(200 ± 10) μg/L vs.(570 ±22) μ g/L] (P ＜0.05).After treatment 3 weeks,the levels of AFP and CEA achieved normal.Conclusions TACE in treatment for primary liver cancer can achieve better therapeutic effect,significantly improve the symptoms,decrease the levels of AFP and CEA.To control the indication and contraindication,perform TACE in time can decrease mortality,improve prognosis,and is valuable in clinic.
