中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
10期
65-66
,共2页
心力衰竭%抑郁症%药物疗法
心力衰竭%抑鬱癥%藥物療法
심력쇠갈%억욱증%약물요법
Congestive heart failure%Depression%Drug therapy
目的 探讨抗抑郁药物治疗对慢性心力衰竭伴抑郁症患者心功能和生活质量的影响以及氟西汀的安全性和有效性.方法 慢性心力衰竭伴抑郁症的患者84例,随机分为治疗组44例和对照组40例.治疗组在常规药物治疗基础上加抗抑郁治疗,给予氟西汀20mg,早晨顿服1次;对照组只给常规药物治疗.12周后,用生活质量量表评价生活质量,用超声心动图测定左心室射血分数.结果 治疗后治疗组较对照组生活质量量表得分高(P＜0.05),左心室射血分数较高(0.56±0.06 vs 0.51±0.06,P＜0.01),且服药期间不良反应极低.结论 对慢性心力衰竭伴抑郁症的患者,抗抑郁治疗能改善患者的心功能和生活质量,且疗效好、安全性高.
目的 探討抗抑鬱藥物治療對慢性心力衰竭伴抑鬱癥患者心功能和生活質量的影響以及氟西汀的安全性和有效性.方法 慢性心力衰竭伴抑鬱癥的患者84例,隨機分為治療組44例和對照組40例.治療組在常規藥物治療基礎上加抗抑鬱治療,給予氟西汀20mg,早晨頓服1次;對照組隻給常規藥物治療.12週後,用生活質量量錶評價生活質量,用超聲心動圖測定左心室射血分數.結果 治療後治療組較對照組生活質量量錶得分高(P＜0.05),左心室射血分數較高(0.56±0.06 vs 0.51±0.06,P＜0.01),且服藥期間不良反應極低.結論 對慢性心力衰竭伴抑鬱癥的患者,抗抑鬱治療能改善患者的心功能和生活質量,且療效好、安全性高.
목적 탐토항억욱약물치료대만성심력쇠갈반억욱증환자심공능화생활질량적영향이급불서정적안전성화유효성.방법 만성심력쇠갈반억욱증적환자84례,수궤분위치료조44례화대조조40례.치료조재상규약물치료기출상가항억욱치료,급여불서정20mg,조신돈복1차;대조조지급상규약물치료.12주후,용생활질량량표평개생활질량,용초성심동도측정좌심실사혈분수.결과 치료후치료조교대조조생활질량량표득분고(P＜0.05),좌심실사혈분수교고(0.56±0.06 vs 0.51±0.06,P＜0.01),차복약기간불량반응겁저.결론 대만성심력쇠갈반억욱증적환자,항억욱치료능개선환자적심공능화생활질량,차료효호、안전성고.
Objective To investigate the effect of antidepression drugs on cardiac function and quality of life in congestive heart failure (CHF) patients with depression,and to investigate the safety and effectiveness of fluoxetine.Methods Eighty-four CHF patients combined with depression were randomly divided into the treatment group (n =44) and the control group (n =40).The patients in treatment group received antidepression treatment in addition to routine medication treatment,Fluoxetine 20 mg per day;While the patients in the control group only received routine medication treatment.Twelve weeks later,the patients' quality of life were evaluated by quality of life index questionnaire.The left ventricular ejection fraction (LVEF) was examined by echocardiography.Results As compared with the control group,the quality of life in treatment group was improved significantly ( P ＜0.05),and LVEF was significantly higher (0.56 ± 0.06 vs 0.51 ± 0.06,P ＜ 0.01 ).There were few adverse effects in the treatment group.Conclusions Antidepression treatment can obviously improve the patients' qualiy of life and cardiac function in CHF patients with depression.Fluoxetine is safe and effectve for those patients.
