CAJ | 학술논문

目的:回顾性分析140例三阴乳腺癌病例,旨在了解该院三阴乳腺癌生存及复发情况.方法:收集中山大学肿瘤防治中心2000～2002年间收治的1 125例乳腺癌手术病例,其中140例三阴乳腺癌(其诊断主要基于免疫组化)的病例资料,回顾性分析患者生存情况以及肿瘤复发转移方式.结果:140例三阴乳腺癌患者中位随访时间58个月,5年无病生存率为65.7%,5年总生存率为73.4%.同时期(2000～2002年)该院手术后总的乳腺癌共1 125例,5年生存率为86.7%.二者生存率比较(73.4%VS 86.7%)有统计学意义.78例绝经前三阴乳腺癌患者5年生存率为75.0%,62例绝经后患者5年生存率为71.3%.有45例三阴乳腺癌发生复发转移,其中17例(37.8%)肝转移,23例(51.1%)肺转移,7例(15.6%)脑转移.结论:与总的乳腺癌比较,三阴乳腺癌的预后更差;绝经前后三阴乳腺癌生存率比较无统计学意义;淋巴结阳性三阴乳腺癌生存差于淋巴结阴性的三阴乳腺癌;与总的乳腺癌比较,三阴乳腺癌复发转移以内脏(肺,肝)转移和脑转移多见.
목적:회고성분석140례삼음유선암병례,지재료해해원삼음유선암생존급복발정황.방법:수집중산대학종류방치중심2000～2002년간수치적1 125례유선암수술병례,기중140례삼음유선암(기진단주요기우면역조화)적병례자료,회고성분석환자생존정황이급종류복발전이방식.결과:140례삼음유선암환자중위수방시간58개월,5년무병생존솔위65.7%,5년총생존솔위73.4%.동시기(2000～2002년)해원수술후총적유선암공1 125례,5년생존솔위86.7%.이자생존솔비교(73.4%VS 86.7%)유통계학의의.78례절경전삼음유선암환자5년생존솔위75.0%,62례절경후환자5년생존솔위71.3%.유45례삼음유선암발생복발전이,기중17례(37.8%)간전이,23례(51.1%)폐전이,7례(15.6%)뇌전이.결론:여총적유선암비교,삼음유선암적예후경차;절경전후삼음유선암생존솔비교무통계학의의;림파결양성삼음유선암생존차우림파결음성적삼음유선암;여총적유선암비교,삼음유선암복발전이이내장(폐,간)전이화뇌전이다견.
Objective:Retrospectively analyzed 140 triple-negative cases from Cancer Center of Sun Yat-sen University between 2000 and 2002 years to get the message about survival and recurrence of triple negative hreast cancers.Methods:Collected 1 125 postoperative breast cancers from Cancer Center of Sun Yat-sen University between 2000 and 2002 years (including 140 triple-negative patients,diagnosis mainly based on immunohistochemistry) and analyzed recurrence,metastases and survival of them.Results:As of November 2007,with a median follow-up time of 56.4±22.8 months,78 patients are premenopausal.At 5 years,the triple negative had a disease-free survival rate 65.7% and had a survival rate 73.4%.There were 1 125 postoperative breast cancers which had survival rate 86.7% at 5 years in Cancer Center of Sun Yat-sen University between 2000 and 2002 years.Of 140 triple negative breast cancers,78 premenopausal with the 5-year survival rate 75.0%,62 post-menopausal with the 5-year survival rate 71.3%.Among 45 recurrent and metastatic (of 140 triple negative breast cancers),Found 17(37.8%) liver metastatic,23(51.1%)lung metastatic,7 (15.6%) brain metastatic.Conclusion:Triple negative with poorer survival at five years compared with the whole breast cancers over the same time interval (73.4% v 86.7%,respectively).Whether triple negative breast cancers were premenopausal or post-menopausal,the difference of 5-year survival rate was not statistically significant (75.0% v 71.3%,respectively).The triple negative breast cancers with positive lymph node had poorer survival than the triple negative breast cancers with negative lymph node;Internal organ metastases and brain metastases occurred more easily for triple negative breast cancers.