CAJ | 학술논문

目的研究黄芪对妊娠期糖尿病抗氧化活性及其临床疗效的影响.方法选择84例妊娠期糖尿病孕妇,经过规则饮食控制需药物治疗,予胰岛素控制血糖稳定后,随机分为继续胰岛素治疗组(43例)和胰岛素联合黄芪治疗组(41例),测定两组血液超氧化物岐化酶(SOD)的活性、脂质过氧化物(LPO)的水解产物丙二醛(MDA)的含量及血脂、肾功等.结果加用黄芪治疗后,患者血清SOD较对照组明显上升,而MDA较对照组明显下降.黄芪治疗组肾功能及血脂均较对照组下降.结论黄芪可有效控制血糖的升高,减少自由基生成,提高机体抗氧化损伤能力,改善机体功能,在妊娠期糖尿病及其并发症的防治中起一定作用.
목적 연구황기대임신기당뇨병항양화활성급기림상료효적영향.방법 선택84례임신기당뇨병잉부,경과규칙음식공제수약물치료,여이도소공제혈당은정후,수궤분위계속이도소치료조(43례)화이도소연합황기치료조(41례),측정량조혈액초양화물기화매(SOD)적활성、지질과양화물(LPO)적수해산물병이철(MDA)적함량급혈지、신공등.결과 가용황기치료후,환자혈청SOD교대조조명현상승,이MDA교대조조명현하강.황기치료조신공능급혈지균교대조조하강.결론 황기가유효공제혈당적승고,감소자유기생성,제고궤체항양화손상능력,개선궤체공능,재임신기당뇨병급기병발증적방치중기일정작용.
Objective To evaluate the antioxidant activity of astragalus and its therapeutic effect on gestational diabetes.Methods Eighty-four pregnant women with gestational diabetes were divided into insulin and insulin plus astragalus groups after regular dietary control and insulin treatment to maintain stable blood glucose level.The 43 patients in insulin group received insulin injection,whereas the 41 patients in the other group received treatment with both insulin and astragalus.The SOD activity,MDA level,blood lipids and renal function were determined in both groups after the treatments.Results The patients with both insulin and astragalus treatments showed significantly increased serum SOD activity and decreased MDA level,renal function and blood lipids in comparison with those with exclusive insulin treatment.Conclusion Astragalus can effectively control blood glucose,reduce the free radicals,and promote the antioxidative activity,and may play a role in the prevention and treatment of gestational diabetes.