CAJ | 학술논문

目的探讨2型糖尿病(T2DM)患者外周血基质细胞衍生因子1(SDF-1)水平与大血管并发症的关系.方法测定55例无微血管并发症的T2DM患者和26名健康对照者外周血中SDF-1水平、内皮祖细胞(EPCs)数量、EPCs表面SDF-1的受体CXCR4表达率.糖尿病患者分单纯糖尿病组、大血管病变组.结果 SDF-1水平和EPCs数量对照组、单纯糖尿病组、大血管病变组依次降低(P＜0.05或0.01);单纯糖尿病组、对照组、大血管病变组CXCR4表达率依次降低(P＜0.05或0.01);SDF-1水平与EPCs数量成正相关(r=0.327,P＜0.05),颈动脉内膜中层厚度与SDF-1、EPCs负相关(r=-0.342、-0.298,P＜0.05).结论 T2DM患者外周血中SDF-1/CXCR4轴的变化与大血管并发症的发生、发展有关.
목적 탐토2형당뇨병(T2DM)환자외주혈기질세포연생인자1(SDF-1)수평여대혈관병발증적관계.방법 측정55례무미혈관병발증적T2DM환자화26명건강대조자외주혈중SDF-1수평、내피조세포(EPCs)수량、EPCs표면SDF-1적수체CXCR4표체솔.당뇨병환자분단순당뇨병조、대혈관병변조.결과 SDF-1수평화EPCs수량대조조、단순당뇨병조、대혈관병변조의차강저(P＜0.05혹0.01);단순당뇨병조、대조조、대혈관병변조CXCR4표체솔의차강저(P＜0.05혹0.01);SDF-1수평여EPCs수량성정상관(r=0.327,P＜0.05),경동맥내막중층후도여SDF-1、EPCs부상관(r=-0.342、-0.298,P＜0.05).결론 T2DM환자외주혈중SDF-1/CXCR4축적변화여대혈관병발증적발생、발전유관.
Objective To study the association of serum level of stromal cell-derived factor-1(SDF-1) and its receptor CXCR4 of endothelial progenitor cells (EPCs)from peripheral blood with macrovascular complication of type 2 diabetes mellitus(T2DM). Methods The study subjects included simple diabetics (n=25), macrovascular complication group (n)=30) and healthy control (n=26). The level of serum SDF-1, the positive rate of CXCR4 on EPCs and the number of EPCs were determined. Results SDF-1 level and EPCs number were decreased one by one from control group to simple diabetic group and to the macrovascular complications group(P<0.05 or 0.01). CXCR4 expression rate were significantly decreased one by one from the simple diabetic group to the control group and to the macrovascular complications group (P<0.05 or 0.01). SDF-1 level was positively correlated with EPCs number. (r=0.327,P<0.05), carotid intima-media thickness were negatively correlated with SDF-1 and EPCs (r=-0.342,-0.298, P<0.05) in T2DM. Conclusion SDF-1/CXCR4 may be related to macrovascular complications in patients with T2DM.