国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
4期
251-256
,共6页
刘丹%孙建功%孙洪英%张广炜%张佳%王贵喜%杨静%宋瑞琦
劉丹%孫建功%孫洪英%張廣煒%張佳%王貴喜%楊靜%宋瑞琦
류단%손건공%손홍영%장엄위%장가%왕귀희%양정%송서기
连接蛋白类%多态现象,遗传学%卒中%脑缺血
連接蛋白類%多態現象,遺傳學%卒中%腦缺血
련접단백류%다태현상,유전학%졸중%뇌결혈
Connexins%Polymorphism,Genetic%Stroke%Brain Ischemia
目的 探讨连接蛋白37(connexin37,Cx37)基因C1019T多态性与缺血性卒中及其转归的关系.方法 采用限制性片段长度多态性分析技术检测缺血性卒中组和对照组Cx37基因C1019T多态性的分布,采用改良Rankin量表(modified Rankin Scale,mRS)评价发病后3个月时神经功能转归.结果 纳入急性缺血性卒中患者232例,其中转归良好(mRS评分＜3分)210例,转归不良(mRS评分≥3分)22例；对照组235例.缺血性卒中组TT基因型(12.93％对6.39％；x2=10.087,P=0.006)和T等位基因(31.25％对21.49％;x2 =11.466,P=0.001)频率显著高于对照组.多变量logistic回归分析显示,TT基因型[优势比(odds ratio,OR)5.794,95％可信区间(confidence interval,CI)1.405～23.894;P=0.015]和T等位基因(OR 131.016,95％ CI 6.943～2472.477；P =0.001)可显著增高缺血性卒中的发病风险.单因素分析显示,TT基因型(OR 0.650,95％ CI 0.144～2.934;P=0.575)、CT基因型(OR 0.622,95％ CI 0.234～1.655；P=0.342)、CC基因型(OR 0.654,95％ CI0.268～1.595;P=0.350)与缺血性卒中转归均无显著相关性.结论 Cx37 1019TT基因型和T等位基因可增高缺血性卒中风险,T等位基因是缺血性卒中的遗传易感因素之一,但其基因多态性与缺血性卒中发病3个月时的转归无关.
目的 探討連接蛋白37(connexin37,Cx37)基因C1019T多態性與缺血性卒中及其轉歸的關繫.方法 採用限製性片段長度多態性分析技術檢測缺血性卒中組和對照組Cx37基因C1019T多態性的分佈,採用改良Rankin量錶(modified Rankin Scale,mRS)評價髮病後3箇月時神經功能轉歸.結果 納入急性缺血性卒中患者232例,其中轉歸良好(mRS評分＜3分)210例,轉歸不良(mRS評分≥3分)22例；對照組235例.缺血性卒中組TT基因型(12.93％對6.39％；x2=10.087,P=0.006)和T等位基因(31.25％對21.49％;x2 =11.466,P=0.001)頻率顯著高于對照組.多變量logistic迴歸分析顯示,TT基因型[優勢比(odds ratio,OR)5.794,95％可信區間(confidence interval,CI)1.405～23.894;P=0.015]和T等位基因(OR 131.016,95％ CI 6.943～2472.477；P =0.001)可顯著增高缺血性卒中的髮病風險.單因素分析顯示,TT基因型(OR 0.650,95％ CI 0.144～2.934;P=0.575)、CT基因型(OR 0.622,95％ CI 0.234～1.655；P=0.342)、CC基因型(OR 0.654,95％ CI0.268～1.595;P=0.350)與缺血性卒中轉歸均無顯著相關性.結論 Cx37 1019TT基因型和T等位基因可增高缺血性卒中風險,T等位基因是缺血性卒中的遺傳易感因素之一,但其基因多態性與缺血性卒中髮病3箇月時的轉歸無關.
목적 탐토련접단백37(connexin37,Cx37)기인C1019T다태성여결혈성졸중급기전귀적관계.방법 채용한제성편단장도다태성분석기술검측결혈성졸중조화대조조Cx37기인C1019T다태성적분포,채용개량Rankin량표(modified Rankin Scale,mRS)평개발병후3개월시신경공능전귀.결과 납입급성결혈성졸중환자232례,기중전귀량호(mRS평분＜3분)210례,전귀불량(mRS평분≥3분)22례；대조조235례.결혈성졸중조TT기인형(12.93％대6.39％；x2=10.087,P=0.006)화T등위기인(31.25％대21.49％;x2 =11.466,P=0.001)빈솔현저고우대조조.다변량logistic회귀분석현시,TT기인형[우세비(odds ratio,OR)5.794,95％가신구간(confidence interval,CI)1.405～23.894;P=0.015]화T등위기인(OR 131.016,95％ CI 6.943～2472.477；P =0.001)가현저증고결혈성졸중적발병풍험.단인소분석현시,TT기인형(OR 0.650,95％ CI 0.144～2.934;P=0.575)、CT기인형(OR 0.622,95％ CI 0.234～1.655；P=0.342)、CC기인형(OR 0.654,95％ CI0.268～1.595;P=0.350)여결혈성졸중전귀균무현저상관성.결론 Cx37 1019TT기인형화T등위기인가증고결혈성졸중풍험,T등위기인시결혈성졸중적유전역감인소지일,단기기인다태성여결혈성졸중발병3개월시적전귀무관.
Objective To investigate the correlation between cornexin37 (Cx37) CI019T polymorphism and ischemic stroke and its outcome.Methods Restriction fragment length polymorphism analysis was used to detect the distribution of Cx37 C1019T polymorphism in a ischemic stroke group and a control group.The modified Rankin scale (mRS) was used to evaluate the neurological outcome at 3 months after onset.Results A total of 235 patients in the control group,and 232 patients in the ischemic stroke goup were recruited.In the ischemic stroke group,210 had a good outcome (mRS ＜3) and 22 had a poor outcome (mRS≥ 3).The TT genotype (12.93％ vs.6.39％ ; x2 =10.087,P =0.006) and T allele (31.25％ vs.21.49％ ; x2 =11.466,P=0.001) frequency in the ischemic stroke group were significantly higher than those in the control group.Multivariatelogistic regression analysis showed that TT genotype (odds ratio [OR] 5.794; 95％ confidence interval [CI] 1.405-23.894; P =0.015) and T allele (OR 131.016,95％ CI 6.943 -2 472.477; P =0.001)signifkantly increased the risk of ischemic stroke.Univariate analysis showed that TT genotype (OR 0.650,95％ CI 0.144 - 2,934; P =0.575),CT genotype (OR 0.622,95％ CI 0.234 - 1.655; P =0.342),and CC genotype (OR 0.654,95％ CI 0.268 - 1.595; P =0.350) had no significant correlation with the outcome of ischemic stroke.Conclusions Cx37 1019TT genotype and T allele may increase the risk of ischemic stroke.T allele is one of genetic susceptibility factors for ischemic stroke; however,its gene polymorphism is not associated with the outcome of ischemic stroke at 3 months after onset.
