中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
1期
20-22,26
,共4页
糖尿病血管病变/免疫学/代谢%白细胞介素1β/代谢%肿瘤坏死因子α/代谢%热休克蛋白质类/代谢
糖尿病血管病變/免疫學/代謝%白細胞介素1β/代謝%腫瘤壞死因子α/代謝%熱休剋蛋白質類/代謝
당뇨병혈관병변/면역학/대사%백세포개소1β/대사%종류배사인자α/대사%열휴극단백질류/대사
Diabetic angiopathies/IM/ME%Interleukin-1beta/ME%Tumor necrosis factor-alpha/ME%Heat-shock proteins/ME
目的 观察免疫炎性反应标志物在2型糖尿病大血管病变患者的表达及相关性.方法 收集本院住院治疗120例2型糖尿病患者及60例正常体检者的病史和临床生化资料,2型糖尿病患者根据有无大血管病变分成两组,单纯2型糖尿病组与2型糖尿病大血管病变组.ELISA法分别测定两组患者的免疫炎性反应标记物IL-1β、TNF-α及Hs-CRP.分析免疫炎性反应与2型糖尿病大血管病变之间的关系.结果 2型糖尿病大血管病变组患者血FBG、PPG、HbA1c、Hs-CRP及TNF-α水平[(9.86±1.79 )mmol/L、(14.45±5.48) mmol/L、(11.43±3.25)％、(6.79±3.71) mg/L和(1.99±0.65) ng/ml]高于单纯2型糖尿病组[(7.25±0.64) mmol/L、(10.45±2.89) mmol/L、(8.56±1.58)％、(4.72±2.39) mg/L和(1.24±0.44) ng/ml,P＜0.05].多因素相关分析示,Hs-CRP、TNF-α和HbA1c是2型糖尿病合并大血管病变的相关危险因素.结论 免疫炎性反应参与了2型糖尿病大血管病变的发生发展,而Hs-CRP、TNF-α及HbA1c是2型糖尿病合并大血管病变的相关危险因素.
目的 觀察免疫炎性反應標誌物在2型糖尿病大血管病變患者的錶達及相關性.方法 收集本院住院治療120例2型糖尿病患者及60例正常體檢者的病史和臨床生化資料,2型糖尿病患者根據有無大血管病變分成兩組,單純2型糖尿病組與2型糖尿病大血管病變組.ELISA法分彆測定兩組患者的免疫炎性反應標記物IL-1β、TNF-α及Hs-CRP.分析免疫炎性反應與2型糖尿病大血管病變之間的關繫.結果 2型糖尿病大血管病變組患者血FBG、PPG、HbA1c、Hs-CRP及TNF-α水平[(9.86±1.79 )mmol/L、(14.45±5.48) mmol/L、(11.43±3.25)％、(6.79±3.71) mg/L和(1.99±0.65) ng/ml]高于單純2型糖尿病組[(7.25±0.64) mmol/L、(10.45±2.89) mmol/L、(8.56±1.58)％、(4.72±2.39) mg/L和(1.24±0.44) ng/ml,P＜0.05].多因素相關分析示,Hs-CRP、TNF-α和HbA1c是2型糖尿病閤併大血管病變的相關危險因素.結論 免疫炎性反應參與瞭2型糖尿病大血管病變的髮生髮展,而Hs-CRP、TNF-α及HbA1c是2型糖尿病閤併大血管病變的相關危險因素.
목적 관찰면역염성반응표지물재2형당뇨병대혈관병변환자적표체급상관성.방법 수집본원주원치료120례2형당뇨병환자급60례정상체검자적병사화림상생화자료,2형당뇨병환자근거유무대혈관병변분성량조,단순2형당뇨병조여2형당뇨병대혈관병변조.ELISA법분별측정량조환자적면역염성반응표기물IL-1β、TNF-α급Hs-CRP.분석면역염성반응여2형당뇨병대혈관병변지간적관계.결과 2형당뇨병대혈관병변조환자혈FBG、PPG、HbA1c、Hs-CRP급TNF-α수평[(9.86±1.79 )mmol/L、(14.45±5.48) mmol/L、(11.43±3.25)％、(6.79±3.71) mg/L화(1.99±0.65) ng/ml]고우단순2형당뇨병조[(7.25±0.64) mmol/L、(10.45±2.89) mmol/L、(8.56±1.58)％、(4.72±2.39) mg/L화(1.24±0.44) ng/ml,P＜0.05].다인소상관분석시,Hs-CRP、TNF-α화HbA1c시2형당뇨병합병대혈관병변적상관위험인소.결론 면역염성반응삼여료2형당뇨병대혈관병변적발생발전,이Hs-CRP、TNF-α급HbA1c시2형당뇨병합병대혈관병변적상관위험인소.
Objective To investigate the effect of immunological and inflammatory reactions on type 2 diabetic macrovascular disease.Methods 120 patients with type 2 diabetes mellitus and 60 health controls were enrolled in this study.The patients were divided into two sub - groups,type 2 diabetes mellitus group and type 2 diabetic macrovascular disease group.The markers of immunological and inflammatory reactions were detected,and the main associated factors were collected and analyzed by one -way ANOVA and logistic regression.Results The level of FBG,PPG,HbA1c,Hs-CRP and TNF-αt [ (9.86 ± 1.79)mmol/L,( 14.45 ±5.48) mmol/L,( 11.43 ±3.25) ％,(6.79 ±3.71 )mg/L,( 1.99 ±0.65) ng/ml] in the group of type 2 diabetic macrovascular disease group were higher than type 2 diabetes mellitus group [ (7,25±0.64)mmol/L,(10.45 t2.89) mmol/L,(8.56 ±1.58)％,(4.72 ±2.39) ag/L,(1.24 ±0.44) ng/ml,P ＜ 0.05 ].The risk factors in type 2 diabetic macrovascular disease were TNF-α,Hs-CRP and HbA1 c.Conclusions Immunological and inflammatory reactions play a key role in type 2 diabetic macrovascular disease.
